Literature DB >> 4724482

Perfluorocarbons having a short dwell time in the liver.

L C Clark, F Becattini, S Kaplan, V Obrock, D Cohen, C Becker.   

Abstract

Perfluorinated organic liquids are useful as high capacity oxygen and carbon dioxide solvents. After intravenous infusion most of these perfluorinated emulsions are deposited in the liver and spleen in a matter of days, where they remain for the lifetime of the animal. Hence, while they may be useful as isolated organ perfusion media their value as artificial blood is limited. A family of perfluorocarbons has now been discovered, which, although deposited in the liver after circulation in the blood, leave the liver to be excreted via the lungs and skin in a matter of days without apparent harmn to the animal.

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Year:  1973        PMID: 4724482     DOI: 10.1126/science.181.4100.680

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  6 in total

1.  Egress of large quantities of heavy liquids from exposed choroid: a route for possible tumor dissemination via vortex veins in endoresection of choroidal melanoma.

Authors:  A M Joussen; D Wong
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2015-01-10       Impact factor: 3.117

2.  Sex-related difference in the inductions by perfluoro-octanoic acid of peroxisomal beta-oxidation, microsomal 1-acylglycerophosphocholine acyltransferase and cytosolic long-chain acyl-CoA hydrolase in rat liver.

Authors:  Y Kawashima; N Uy-Yu; H Kozuka
Journal:  Biochem J       Date:  1989-07-15       Impact factor: 3.857

3.  Effects of potential blood substitutes (perfluorochemicals) on rat liver and spleen.

Authors:  J Lutz; P Metzenauer
Journal:  Pflugers Arch       Date:  1980-09       Impact factor: 3.657

4.  Transport of nitric oxide by perfluorocarbon emulsion.

Authors:  Daniel Ortiz; Pedro Cabrales; Juan C Briceño
Journal:  Biotechnol Prog       Date:  2013-09-10

5.  Cytotoxic and cytolytic activity of nonadecafluoro-n-decanoic acid on Acholeplasma laidlawii.

Authors:  A Liss; J C Pfeil; D Levitt
Journal:  Appl Environ Microbiol       Date:  1987-06       Impact factor: 4.792

6.  A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling.

Authors:  Daniel C Leslie; Anna Waterhouse; Julia B Berthet; Thomas M Valentin; Alexander L Watters; Abhishek Jain; Philseok Kim; Benjamin D Hatton; Arthur Nedder; Kathryn Donovan; Elana H Super; Caitlin Howell; Christopher P Johnson; Thy L Vu; Dana E Bolgen; Sami Rifai; Anne R Hansen; Michael Aizenberg; Michael Super; Joanna Aizenberg; Donald E Ingber
Journal:  Nat Biotechnol       Date:  2014-10-12       Impact factor: 54.908

  6 in total

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