Literature DB >> 2570571

Sex-related difference in the inductions by perfluoro-octanoic acid of peroxisomal beta-oxidation, microsomal 1-acylglycerophosphocholine acyltransferase and cytosolic long-chain acyl-CoA hydrolase in rat liver.

Y Kawashima1, N Uy-Yu, H Kozuka.   

Abstract

Inductions by perfluoro-octanoic acid (PFOA) of hepatomegaly, peroxisomal beta-oxidation, microsomal 1-acylglycerophosphocholine acyltransferase and cytosolic long-chain acyl-CoA hydrolase were compared in liver between male and female rats. Marked inductions of these four parameters were seen concurrently in liver of male rats, whereas the inductions in liver of female rats were far less pronounced. The sex-related difference in the response of rat liver to PFOA was much more marked than that seen with p-chlorophenoxyisobutyric acid (clofibric acid) or 2,2'-(decamethylenedithio)diethanol (tiadenol). Hormonal manipulations revealed that this sex-related difference in the inductions is strongly dependent on sex hormones, namely that testosterone is necessary for the inductions, whereas oestradiol prevented the inductions by PFOA.

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Year:  1989        PMID： 2570571      PMCID： PMC1138866          DOI： 10.1042/bj2610595

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  33 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  Microsomal cytochrome P-452 induction and peroxisome proliferation by hypolipidaemic agents in rat liver. A mechanistic inter-relationship.

Authors:  R Sharma; B G Lake; J Foster; G G Gibson
Journal:  Biochem Pharmacol       Date:  1988-04-01       Impact factor: 5.858

3.  Co-induction of microsomal cytochrome P-452 and the peroxisomal fatty acid beta-oxidation pathway in the rat by clofibrate and di-(2-ethylhexyl)phthalate. Dose-response studies.

Authors:  R Sharma; B G Lake; G G Gibson
Journal:  Biochem Pharmacol       Date:  1988-04-01       Impact factor: 5.858

4.  Carboxylic metabolites of tiadenol as "proximate" inducers of hepatic peroxisomal beta-oxidation activity.

Authors:  R Maffei Facino; M Carini; O Tofanetti
Journal:  Pharmacol Res Commun       Date:  1988-04

Review 5.  Peroxisome proliferation and hepatocarcinogenesis.

Authors:  M S Rao; J K Reddy
Journal:  Carcinogenesis       Date:  1987-05       Impact factor: 4.944

Review 6.  The effect of peroxisome proliferators on microsomal, peroxisomal, and mitochondrial enzyme activities in the liver and kidney.

Authors:  J M Hawkins; W E Jones; F W Bonner; G G Gibson
Journal:  Drug Metab Rev       Date:  1987       Impact factor: 4.518

7.  Lack of evidence for a hepatic peroxisome proliferator receptor and an explanation for the binding of hypolipidaemic drugs to liver homogenates.

Authors:  M N Milton; C R Elcombe; G E Kass; G G Gibson
Journal:  Biochem Pharmacol       Date:  1988-03-01       Impact factor: 5.858

8.  Elimination and toxicity of perfluorooctanoic acid during subchronic administration in the Wistar rat.

Authors:  H Hanhijärvi; M Ylinen; A Kojo; V M Kosma
Journal:  Pharmacol Toxicol       Date:  1987-07

9.  Peroxisome proliferator-binding protein: identification and partial characterization of nafenopin-, clofibric acid-, and ciprofibrate-binding proteins from rat liver.

Authors:  N D Lalwani; K Alvares; M K Reddy; M N Reddy; I Parikh; J K Reddy
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

10.  Biochemical and morphological studies of ammonium perfluorooctanoate-induced hepatomegaly and peroxisome proliferation.

Authors:  T P Pastoor; K P Lee; M A Perri; P J Gillies
Journal:  Exp Mol Pathol       Date:  1987-08       Impact factor: 3.362
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  7 in total

1.  Sex-related differences in the enhancing effects of perfluoro-octanoic acid on stearoyl-CoA desaturase and its influence on the acyl composition of phospholipid in rat liver. Comparison with clofibric acid and tiadenol.

Authors:  Y Kawashima; N Uy-Yu; H Kozuka
Journal:  Biochem J       Date:  1989-11-01       Impact factor: 3.857

2.  Dose-related effects of perfluorodecanoic acid on growth, feed intake and hepatic peroxisomal beta-oxidation.

Authors:  T Borges; L W Robertson; R E Peterson; H P Glauert
Journal:  Arch Toxicol       Date:  1992       Impact factor: 5.153

Review 3.  Mechanisms of regulation of liver fatty acid-binding protein.

Authors:  R M Kaikaus; W K Chan; P R Ortiz de Montellano; N M Bass
Journal:  Mol Cell Biochem       Date:  1993 Jun 9-23       Impact factor: 3.396

4.  Dehydroepiandrosterone 3 beta-sulphate is an endogenous activator of the peroxisome-proliferation pathway: induction of cytochrome P-450 4A and acyl-CoA oxidase mRNAs in primary rat hepatocyte culture and inhibitory effects of Ca(2+)-channel blockers.

Authors:  P A Ram; D J Waxman
Journal:  Biochem J       Date:  1994-08-01       Impact factor: 3.857

5.  The up-regulation of hepatic acyl-CoA oxidase and cytochrome P450 4A1 mRNA expression by dietary oxidized frying oil is comparable between male and female rats.

Authors:  Pei-Min Chao; Shan-Ching Hsu; Fu-Jung Lin; Yi-Jen Li; Ching-Jang Huang
Journal:  Lipids       Date:  2004-03       Impact factor: 1.880

6.  The effects of perfluoro-octanoic acid on hepatic peroxisome proliferation and related parameters show no sex-related differences in mice.

Authors:  A K Sohlenius; K Andersson; J W DePierre
Journal:  Biochem J       Date:  1992-08-01       Impact factor: 3.857

7.  Sex-different hepaticglycogen content and glucose output in rats.

Authors:  Carolina Gustavsson; Kamal Yassin; Erik Wahlström; Louisa Cheung; Johan Lindberg; Kerstin Brismar; Claes-Göran Ostenson; Gunnar Norstedt; Petra Tollet-Egnell
Journal:  BMC Biochem       Date:  2010-09-23       Impact factor: 4.059
  7 in total

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