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Literature DB >> 4722035

Glucocerebrosidase: reconstitution of activity from macromolecular components.

M W Ho, J S O'Brien, N S Radin, J S Erickson.

Abstract

Glucocerebrosidase activity was reconstituted in vitro from a soluble glycoprotein factor (P) and a particle-bound factor (C). The physiological significance of the system is discussed.

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Substances：

Year: 1973 PMID： 4722035 PMCID： PMC1177451 DOI： 10.1042/bj1310173

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

9 in total

1. METABOLISM OF GLUCOCEREBROSIDES. II. EVIDENCE OF AN ENZYMATIC DEFICIENCY IN GAUCHER'S DISEASE.

Authors: R O BRADY; J N KANFER; D SHAPIRO
Journal: Biochem Biophys Res Commun Date: 1965-01-18 Impact factor: 3.575

2. IN VIVO CONVERSIONS OF CEREBROSIDE AND CERAMIDE IN RAT BRAIN.

Authors: K C KOPACZYK; N S RADIN
Journal: J Lipid Res Date: 1965-01 Impact factor: 5.922

3. A simple method for the isolation and purification of total lipides from animal tissues.

Authors: J FOLCH; M LEES; G H SLOANE STANLEY
Journal: J Biol Chem Date: 1957-05 Impact factor: 5.157

4. Ribonucleic acid synthesis by Escherichia coli C3000/L after infection by the ribonucleic acid coliphage ZIK/1, and properties of coliphage-ZIK/1 ribonucleic acid.

Authors: D H Bishop
Journal: Biochem J Date: 1965-10 Impact factor: 3.857

5. Detection of the defect of Gaucher's disease and its carrier state in peripheral-blood leucocytes.

Authors: E Beutler; W Kuhl
Journal: Lancet Date: 1970-03-21 Impact factor: 79.321

6. Adult Gaucher's disease: kindred studies and demonstration of a deficiency of acid beta-glucosidase in cultured fibroblasts.

Authors: M W Ho; J Seck; D Schmidt; M L Veath; W Johnson; R O Brady; J S O'Brien
Journal: Am J Hum Genet Date: 1972-01 Impact factor: 11.025

7. Properties of cerebroside galactosidase.

Authors: D M Bowen; N S Radin
Journal: Biochim Biophys Acta Date: 1968-05-01

8. Glycosidases in the nervous system. 3. Separation, purification, and substrate specificities of beta-galactosidases and beta-glucuronidase from brain.

Authors: F B Jungalwala; E Robins
Journal: J Biol Chem Date: 1968-08-25 Impact factor: 5.157

9. Gaucher's disease: deficiency of 'acid' -glucosidase and reconstitution of enzyme activity in vitro.

Authors: M W Ho; J S O'Brien
Journal: Proc Natl Acad Sci U S A Date: 1971-11 Impact factor: 11.205

9 in total

16 in total

Glucocerebrosidase: reconstitution of activity from macromolecular components.

1. METABOLISM OF GLUCOCEREBROSIDES. II. EVIDENCE OF AN ENZYMATIC DEFICIENCY IN GAUCHER'S DISEASE.

2. IN VIVO CONVERSIONS OF CEREBROSIDE AND CERAMIDE IN RAT BRAIN.

3. A simple method for the isolation and purification of total lipides from animal tissues.

4. Ribonucleic acid synthesis by Escherichia coli C3000/L after infection by the ribonucleic acid coliphage ZIK/1, and properties of coliphage-ZIK/1 ribonucleic acid.

5. Detection of the defect of Gaucher's disease and its carrier state in peripheral-blood leucocytes.

6. Adult Gaucher's disease: kindred studies and demonstration of a deficiency of acid beta-glucosidase in cultured fibroblasts.

7. Properties of cerebroside galactosidase.

8. Glycosidases in the nervous system. 3. Separation, purification, and substrate specificities of beta-galactosidases and beta-glucuronidase from brain.

9. Gaucher's disease: deficiency of 'acid' -glucosidase and reconstitution of enzyme activity in vitro.

1. Glucosylceramide and the level of the glucosidase-stimulating proteins.

Review 2. Glycosphingolipid hydrolases: properties and molecular genetics.

3. Rapid partial purification of placental glucocerebroside beta-glucosidase and its entrapment in liposomes.

4. The inhibition of glucosylceramide beta-glucosidase and other acid hydrolases by nucleic acids.

5. Saposin A: second cerebrosidase activator protein.

Review 6. Some aspects of the cellular biochemistry of lysosomal and related glycosidases.

7. Alternate pathways of cerebroside catabolism.

8. Glucocerebrosidase: reconstitution from macromolecular components depends on acidic phospholipids.

9. Identity of 'acid' beta-glucosidase and glucocerebrosidase in human spleen.

10. Hydrolysis of GM1-ganglioside by human liver beta-galactosidase isoenzymes.