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Literature DB >> 4700498

Heterogeneity of 5'-nucleotidase activity in lymphocytes in chronic lymphocytic leukemia.

Abstract

The specific activity of 5'-nucleotidase was determined in lymphocyte plasma membranes from 14 normal subjects and 10 patients with chronic lymphocytic leukemia (CLL). Whereas the enzyme was present in the preparation from normal lymphocytes, in 7 out of 10 CLL patients the membranes had markedly decreased or no detectable 5'-nucleotidase activity. The lack of this activity from the lymphocytes of most patients with CLL constitutes an alteration in a plasma membrane enzyme from the normal cell. The presence of the enzyme in the lymphocytes of some patients with CLL and its decrease in others provide further evidence for biochemical heterogeneity among patients with this disorder.

Entities: Disease Gene Species

Mesh：

Substances：
Nucleotidases

Year: 1973 PMID： 4700498 PMCID： PMC302387 DOI： 10.1172/JCI107298

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

10 in total

1. ADHERENCE AND SEPARATION OF LEUKEMIC CELLS ON GLASS BEAD COLUMNS.

Authors: Y RABINOWITZ
Journal: Blood Date: 1965-07 Impact factor: 22.113

2. The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid.

Authors: B N AMES; D T DUBIN
Journal: J Biol Chem Date: 1960-03 Impact factor: 5.157

3. Characterization of the cell surface receptor for the Agaricus bisporus hemagglutinin.

Authors: C A Presant; S Kornfeld
Journal: J Biol Chem Date: 1972-11-10 Impact factor: 5.157

4. Studies on a reciprocal relationship between nucleoside kinases and 5'-nucleotidase.

Authors: T Arima; T Shirasaka; H Okuda; S Fujii
Journal: Biochim Biophys Acta Date: 1972-08-16

5. Lymphocyte plasma membranes: analysis of proteins and glycoproteins by SDS-gel electrophoresis.

Authors: J Lopes; M Nachbar; D Zucker-Franklin; R Silber
Journal: Blood Date: 1973-01 Impact factor: 22.113

6. Ribonucleic acid-deoxyribonucleic acid hybridization and hybridization--competition studies of the rapidly labeled ribonucleic acid from normal and chronic lymphocytic leukemia lymphocytes.

Authors: P E Neiman; P H Henry
Journal: Biochemistry Date: 1969-01 Impact factor: 3.162

7. Increased proportion of complement-receptor lymphocytes in the peripheral blood of patients with chronic lymphocytic leukemia.

Authors: S Pincus; C Bianco; V Nussenzweig
Journal: Blood Date: 1972-09 Impact factor: 22.113

8. The 5'-nucleotidase of Escherichia coli. I. Purification and properties.

Authors: H C Neu
Journal: J Biol Chem Date: 1967-09-10 Impact factor: 5.157

9. Receptors for complement and immunoglobulin on human leukemic cells and human lymphoblastoid cell lines.

Authors: E M Shevach; R Herberman; M M Frank; I Green
Journal: J Clin Invest Date: 1972-08 Impact factor: 14.808

10. [Lysosomal enzymes in lymphocytes. I. Lymphoreticular diseases: comparison of the enzyme content (acid phosphatase, beta-glucuronidase) in unstimulated lymphocytes with blastic transformation after stimulation with phytohemagglutinin beta-Glucuronidase in vitro].

Authors: G Brittinger; E König; G Cohnen; H G Aberle
Journal: Acta Haematol Date: 1970 Impact factor: 2.195

10 in total

15 in total

1. [Lymphocyte in chronic lymphatic leukemia].

Authors: G Brittinger; W Augener; K Bremer; G Cohnen; S Dabag; K Fischer; E König; P Meusers
Journal: Blut Date: 1975-05

2. Uptake of free adenosine and adenosine from adenosine monophosphate by human peripheral blood lymphocytes: possible kinetic role for ecto-5'-nucleotidase in the regulation of intracellular adenosine.

Authors: T Shah; R J Simpson; A D Webster; T J Peters
Journal: Clin Exp Immunol Date: 1986-10 Impact factor: 4.330

Heterogeneity of 5'-nucleotidase activity in lymphocytes in chronic lymphocytic leukemia.

1. ADHERENCE AND SEPARATION OF LEUKEMIC CELLS ON GLASS BEAD COLUMNS.

2. The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid.

3. Characterization of the cell surface receptor for the Agaricus bisporus hemagglutinin.

4. Studies on a reciprocal relationship between nucleoside kinases and 5'-nucleotidase.

5. Lymphocyte plasma membranes: analysis of proteins and glycoproteins by SDS-gel electrophoresis.

6. Ribonucleic acid-deoxyribonucleic acid hybridization and hybridization--competition studies of the rapidly labeled ribonucleic acid from normal and chronic lymphocytic leukemia lymphocytes.

7. Increased proportion of complement-receptor lymphocytes in the peripheral blood of patients with chronic lymphocytic leukemia.

8. The 5'-nucleotidase of Escherichia coli. I. Purification and properties.

9. Receptors for complement and immunoglobulin on human leukemic cells and human lymphoblastoid cell lines.

10. [Lysosomal enzymes in lymphocytes. I. Lymphoreticular diseases: comparison of the enzyme content (acid phosphatase, beta-glucuronidase) in unstimulated lymphocytes with blastic transformation after stimulation with phytohemagglutinin beta-Glucuronidase in vitro].

1. [Lymphocyte in chronic lymphatic leukemia].

2. Uptake of free adenosine and adenosine from adenosine monophosphate by human peripheral blood lymphocytes: possible kinetic role for ecto-5'-nucleotidase in the regulation of intracellular adenosine.

3. Histochemical observations on 5'-nucleotidase activity in squamous cell carcinomas of the rat.

4. Enzyme histochemical analysis on cryostat sections of human bone marrow.

5. Adenosine deaminase activity in chronic lymphocytic leukemia. Relationship to B- and T-cell subpopulations.

6. 5'-nucleotidase of B and T lymphocytes isolated from human peripheral blood.

7. Biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human T cell lines.

8. Increased ascorbic acid content in chronic lymphocytic leukemia B lymphocytes.

9. Studies on 5'-nucleotidase histochemistry. I. 5'-Nucleotidase activity in the developing esophagus of the mouse.

10. Decreased microviscosity of membrane lipids in leukemic cells: two possible mechanisms.