Literature DB >> 4692223

Evidence for a rate-limiting conformation change in the catalytic steps of the ficin and papain-catalysed hydrolyses of benzyloxycarbonyl-L-lysine p-nitrophenyl ester.

M R Hollaway, M J Hardman.   

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Year:  1973        PMID： 4692223     DOI： 10.1111/j.1432-1033.1973.tb02639.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


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  5 in total

1.  Variation in aspects of cysteine proteinase catalytic mechanism deduced by spectroscopic observation of dithioester intermediates, kinetic analysis and molecular dynamics simulations.

Authors:  J D Reid; S Hussain; S K Sreedharan; T S Bailey; S Pinitglang; E W Thomas; C S Verma; K Brocklehurst
Journal:  Biochem J       Date:  2001-07-15       Impact factor: 3.857

2.  Exploiting temperature-dependent substrate promiscuity for nucleoside analogue activation by thymidine kinase from Thermotoga maritima.

Authors:  Stefan Lutz; Joseph Lichter; Lingfeng Liu
Journal:  J Am Chem Soc       Date:  2007-06-26       Impact factor: 15.419

3.  Mutationally altered rate constants in the mechanism of alkaline phosphatase.

Authors:  S E Halford; M J Schlesinger
Journal:  Biochem J       Date:  1974-09       Impact factor: 3.857

4.  Variation in the pH-dependent pre-steady-state and steady-state kinetic characteristics of cysteine-proteinase mechanism: evidence for electrostatic modulation of catalytic-site function by the neighbouring carboxylate anion.

Authors:  Syeed Hussain; Surapong Pinitglang; Tamara S F Bailey; James D Reid; Michael A Noble; Marina Resmini; Emrys W Thomas; Richard B Greaves; Chandra S Verma; Keith Brocklehurst
Journal:  Biochem J       Date:  2003-06-15       Impact factor: 3.857

5.  Evidence that binding to the s2-subsite of papain may be coupled with catalytically relevant structural change involving the cysteine-25-histidine-159 diad. Kinetics of the reaction of papain with a two-protonic-state reactivity probe containing a hydrophobic side chain.

Authors:  K Brocklehurst; J P Malthouse; M Shipton
Journal:  Biochem J       Date:  1979-11-01       Impact factor: 3.857
  5 in total

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