| Literature DB >> 4689338 |
Abstract
Lymphocytes incubated with phytohemagglutinin or concanavalin A develop the capacity to stimulate autologous lymphocyte transformation. This is not attributable to residual mitogen contaminating the lymphoblastic cell preparation as: (a) the dissociation of mitogen from the lymphoblastic cell preparation increases the degree of stimulation observed and (b) the kinetics of lymphocyte transformation stimulated by phytohemagglutinin-induced lymphoblasts is different from that stimulated by phytohemagglutinin. The appearance of the stimulatory determinants on lymphocytes exposed to phytohemagglutinin precedes morphological transformation.Mesh:
Substances:
Year: 1973 PMID: 4689338 PMCID: PMC2139376 DOI: 10.1084/jem.137.3.799
Source DB: PubMed Journal: J Exp Med ISSN: 0022-1007 Impact factor: 14.307