Literature DB >> 12619898

Synergistic effect of Nicorandil and Amlodipine on tissue defense system during experimental myocardial infarction in rats.

Venkatachalem Sathish1, Kesavarao Kumar Ebenezar, Thiruvengadam Devaki.   

Abstract

The synergistic protective effect of Nicorandil (K(ATP) channel opener) and Amlodipine (calcium channel blocker) on heart tissue antioxidant defense system and lipid profile were examined on isoproterenol induced myocardial infarction in rats. The rats given isoproterenol (150 mg kg(-1) daily, i.p.) for 2 days showed significant changes in antioxidant defense system and lipid profile levels. Pretreatment with Nicorandil (2.5 mg kg(-1) daily, p.o.) and Amlodipine (5.0 mg kg(-1) daily, p.o.) for 3 days significantly prevented these alterations and restored the enzyme activities to near normal. These findings indicate the synergistic protective effect of Nicorandil and Amlodipine on tissue defense system and lipid metabolism during isoproterenol induced cardiac damage.

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Year:  2003        PMID： 12619898     DOI： 10.1023/a:1021612230000

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  34 in total

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  13 in total

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Authors:  Afshin Salimeh; Mustafa Mohammadi; Bahman Rashidi
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7.  Cardioprotective effects of glycyrrhizic acid against isoproterenol-induced myocardial ischemia in rats.

Authors:  Nagaraja Haleagrahara; Julian Varkkey; Srikumar Chakravarthi
Journal:  Int J Mol Sci       Date:  2011-10-21       Impact factor: 5.923

8.  Preconditioning L6 Muscle Cells with Naringin Ameliorates Oxidative Stress and Increases Glucose Uptake.

Authors:  R Dhanya; K B Arun; V M Nisha; H P Syama; P Nisha; T R Santhosh Kumar; P Jayamurthy
Journal:  PLoS One       Date:  2015-07-06       Impact factor: 3.240

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Journal:  EXCLI J       Date:  2013-05-06       Impact factor: 4.068
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