| Literature DB >> 4683130 |
F D Jones, J W Maas, H Dekirmenjian, J A Fawcett.
Abstract
3-Methoxy-4-hydroxyphenylglycol and normetanephrine were analyzed in daily urine specimens of a patient with manic-depressive cycles who was studied longitudinally. The quantities of these catecholamine metabolites excreted into urine were decreased during periods of depression as compared with periods of mania. Urinary excretion of 3-methoxy-4-hydroxyphenylglycol varied cyclically with a period length of approximately 20 days. Changes in this metabolite, and perhaps in normetanephrine, preceded the affective and behavioral shifts.Entities:
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Year: 1973 PMID: 4683130 DOI: 10.1126/science.179.4070.300
Source DB: PubMed Journal: Science ISSN: 0036-8075 Impact factor: 47.728