Literature DB >> 108714

The effect of clonidine withdrawal on total 3-methoxy-4-hydroxyphenylglycol in the rat brain.

S W Tang, D M Helmeste, H C Stancer.   

Abstract

The effect of clonidine withdrawal on the brain norepinephrine system was studied in the rat. Clonidine suppresses brain total 3-methoxy-4-hydroxyphenylglycol (MHPG) significantly and no tolerance to this effect was observed up to 21 days. Cessation of clonidine treatment resulted in an elevation in the level of brain total MHPG. The suitability of the clonidine withdrawal syndrome as a model of bipolar depression is discussed.

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Year:  1979        PMID： 108714     DOI： 10.1007/bf00426802

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  10 in total

1.  Discontinuation of chronic clonidine treatment: evidence for facilitated brain noradrenergic neurotransmission.

Authors:  T H Svensson; U Strömbom
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-08       Impact factor: 3.000

2.  Blood pressure crisis following withdrawal of clonidine (Catapres, Catapresan), with special reference to arterial and urinary catecholamine levels, and suggestions for acute management.

Authors:  L Hansson; S N Hunyor; S Julius; S W Hoobler
Journal:  Am Heart J       Date:  1973-05       Impact factor: 4.749

3.  Daily variations of the urine content of 3-methoxy-4-hydroxyphenylglycol in two manic-depressive patients.

Authors:  P A Bond; F A Jenner; G A Sampson
Journal:  Psychol Med       Date:  1972-02       Impact factor: 7.723

Review 4.  The catecholamine hypothesis of affective disorders: a review of supporting evidence.

Authors:  J J Schildkraut
Journal:  Am J Psychiatry       Date:  1965-11       Impact factor: 18.112

5.  Studies on catecholamines, renin and aldosterone following Catapresan (2-(2,6-dichlor-phenylamine)-2-imidazoline hydrochloride) in hypertensive patients.

Authors:  B Hökfelt; H Hedeland; J F Dymling
Journal:  Eur J Pharmacol       Date:  1970       Impact factor: 4.432

6.  Urinary catecholamine metabolites during behavioral changes in a patient with manic-depressive cycles.

Authors:  F D Jones; J W Maas; H Dekirmenjian; J A Fawcett
Journal:  Science       Date:  1973-01-19       Impact factor: 47.728

7.  Catecholamine metabolism in affective disorders. 3. MHPG and other catecholamine metabolites in patients treated with lithium carbonate.

Authors:  K Greenspan; J J Schildkraut; E K Gordon; L Baer; M S Aronoff; J Durell
Journal:  J Psychiatr Res       Date:  1970-02       Impact factor: 4.791

8.  3-Methoxy-4-hydroxy phenylglycol (MHPG) excretion in depressive states. A pilot study.

Authors:  J W Maas; J Fawcett; H Dekirmenjian
Journal:  Arch Gen Psychiatry       Date:  1968-08

9.  A gas chromatographic-mass spectrometric (GC-MS) assay for 3-methoxy-4-hydroxyphenethyleneglycol and vanilmandelic acid in human serum.

Authors:  S Takahashi; D D Godse; J J Warsh; H C Stancer
Journal:  Clin Chim Acta       Date:  1977-12-01       Impact factor: 3.786

10.  Hypertension and depression: interrelated problems in therapy.

Authors:  F O Simpson; H J Waal-Manning
Journal:  J R Coll Physicians Lond       Date:  1971-10
  10 in total
  5 in total

1.  Clonidine--induced behavioural despair in mice: reversal by antidepressants.

Authors:  M P Parale; S K Kulkarni
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

2.  Alterations in the levels of monoamines in discrete brain regions of clomipramine-induced animal model of endogenous depression.

Authors:  M Vijayakumar; B L Meti
Journal:  Neurochem Res       Date:  1999-03       Impact factor: 3.996

3.  Catecholamine metabolism during clonidine withdrawal.

Authors:  P R Martin; M H Ebert; E K Gordon; H Weingartner; I J Kopin
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

4.  Effect of prolonged clonidine treatment and its withdrawal on noradrenaline turnover in the cerebral cortex and medulla oblongata of the spontaneously hypertensive rat.

Authors:  J Atkinson; N Boillat; T Dennis; S Z Langer; B Scatton
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-07       Impact factor: 3.000

5.  Antagonism of behavioural depression produced by clonidine in the Mongolian gerbil: a potential screening test for antidepressant drugs.

Authors:  W Kostowski; E Malatyńska
Journal:  Psychopharmacology (Berl)       Date:  1983       Impact factor: 4.530
  5 in total

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