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Literature DB >> 4646777

Norephedrines as metabolites of ( 14 C)amphetamine in urine in man.

Abstract

(+/-)-[(14)C]Amphetamine sulphate (20mg) was administered orally to each of two human male subjects, and 80-85% of the (14)C was excreted in the urine in 2 days. The metabolites in the first day's urine were examined quantitatively. Apart from the metabolites previously described (Dring et al., 1970), norephedrine (2.2 and 2.6% of dose in the two subjects respectively) and 4-hydroxynorephedrine (0.3 and 0.4% of dose in the two subjects respectively) were also found.

Entities: Chemical Species

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Year: 1972 PMID： 4646777 PMCID： PMC1174037 DOI： 10.1042/bj1290023

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

6 in total

1. Effect of amphetamine on the pressor response to tyramine: formation of p-hydroxynorephedrine from amphetamine in man.

Authors: J H Cavanaugh; J D Griffith; J A Oates
Journal: Clin Pharmacol Ther Date: 1970 Sep-Oct Impact factor: 6.875

2. Amphetamine abuse. Pattern and effects of high doses taken intravenously.

Authors: J C Kramer; V S Fischman; D C Littlefield
Journal: JAMA Date: 1967-07-31 Impact factor: 56.272

3. The fate of ethyltin and diethyltin derivatives in the rat.

Authors: J W Bridges; D S Davies; R T Williams
Journal: Biochem J Date: 1967-12 Impact factor: 3.857

4. Effects of hydroxyamphetamine (paredrine) on the function of the sympathetic nervous system in normotensive subjects.

Authors: J R Gill; D T Masson; F C Bartter
Journal: J Pharmacol Exp Ther Date: 1967-02 Impact factor: 4.030

5. The metabolic fate of amphetamine in man and other species.

Authors: L G Dring; R L Smith; R T Williams
Journal: Biochem J Date: 1970-02 Impact factor: 3.857

6. Metabolism of ( 14 C)methamphetamine in man, the guinea pig and the rat.

Authors: J Caldwell; L G Dring; R T Williams
Journal: Biochem J Date: 1972-08 Impact factor: 3.857

6 in total

9 in total

1. Observations on the fate of adrenocorticotrophin in isolated rat adrenal-cell suspensions and the separation of an enriched adrenocorticotrophin-sensitive steroidogenic cell fraction.

Authors: G R Bullock; E A Gillam; P J Lowry; C McMartin; J Peters
Journal: Biochem J Date: 1972-09 Impact factor: 3.857

Norephedrines as metabolites of ( 14 C)amphetamine in urine in man.

1. Effect of amphetamine on the pressor response to tyramine: formation of p-hydroxynorephedrine from amphetamine in man.

2. Amphetamine abuse. Pattern and effects of high doses taken intravenously.

3. The fate of ethyltin and diethyltin derivatives in the rat.

4. Effects of hydroxyamphetamine (paredrine) on the function of the sympathetic nervous system in normotensive subjects.

5. The metabolic fate of amphetamine in man and other species.

6. Metabolism of ( 14 C)methamphetamine in man, the guinea pig and the rat.

1. Observations on the fate of adrenocorticotrophin in isolated rat adrenal-cell suspensions and the separation of an enriched adrenocorticotrophin-sensitive steroidogenic cell fraction.

2. The metabolism of amphetamine in dependent subjects.

3. Species differences in the metabolism of norephedrine in man, rabbit and rat.

4. The synthesis of tritium-labelled human corticotropin of high specific radioactivity.

5. The metabolism of (-)-ephedrine in man.

6. Comparative effects of d-amphetamine, l-amphetamine, and methylphenidate on mood in man.

7. Rats become acutely tolerant to cathine after amphetamine or cathinone administration.

8. Metabolism of ( 14 C)methamphetamine in man, the guinea pig and the rat.

9. Wastewater-based tracing of doping use by the general population and amateur athletes.