Literature DB >> 4633288

Characteristics of human antibody to diphtheria toxin.

M Bazaral, P J Goscienski, R N Hamburger.   

Abstract

Human antibody to diphtheria toxin was analyzed with an ammonium sulfate radioimmunoassay. In 15 immune sera with titers of between 0.03 and 25 units/ml, the avidity was similar to that of U.S. standard antitoxin. The proportion of the post-immunization anti-diphtheria antibody specific for fragment A was variable, but in the 10 sera tested constituted a substantial fraction of the antibody. Approximately 2% of healthy adult males tested failed to make an antidiphtheria toxin response after two booster doses of 1.5 Lf adsorbed diphtheriatetanus toxoid, although these nonresponders made precipitating antibody to tetanus toxoid and had normal immunoglobulin levels.

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Year:  1973        PMID： 4633288      PMCID： PMC422649          DOI： 10.1128/iai.7.2.130-136.1973

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  10 in total

1.  A quantitative immunochemical measure of the primary interaction between I BSA and antibody.

Authors:  R S FARR
Journal:  J Infect Dis       Date:  1958 Nov-Dec       Impact factor: 5.226

2.  Combined tetanus-diphtheria immunization of adults: use of small doses of diphtheria toxoid.

Authors:  G EDSALL; J S ALTMAN; A J GASPAR
Journal:  Am J Public Health Nations Health       Date:  1954-12

3.  Human IgG and IgA diphtheria antitoxins in serum, nasal fluids and saliva.

Authors:  R W Newcomb; K Ishizaka; B L DeVald
Journal:  J Immunol       Date:  1969-08       Impact factor: 5.422

4.  Titration of diphtheria and tetanus antitoxins in sera of low titre.

Authors:  J D Van Ramshorst
Journal:  Bull World Health Organ       Date:  1971       Impact factor: 9.408

5.  Relationship between histocompatibility (H-2) genotype and immune responsiveness to low doses of ovalbumin in the mouse.

Authors:  N M Vaz; E M Vaz; B B Levine
Journal:  J Immunol       Date:  1970-06       Impact factor: 5.422

6.  Structure and activity of diphtheria toxin. I. Thiol-dependent dissociation of a fraction of toxin into enzymically active and inactive fragments.

Authors:  R J Collier; J Kandel
Journal:  J Biol Chem       Date:  1971-03-10       Impact factor: 5.157

7.  Structure-activity relationships in diphtheria toxin.

Authors:  D M Gill; A M Pappenheimer
Journal:  J Biol Chem       Date:  1971-03-10       Impact factor: 5.157

8.  Structure and activity of diphtheria toxin. II. Attack by trypsin at a specific site within the intact toxin molecule.

Authors:  R Drazin; J Kandel; R J Collier
Journal:  J Biol Chem       Date:  1971-03-10       Impact factor: 5.157

9.  Observations on the structure of diphtheria toxin.

Authors:  D M Gill; L L Dinius
Journal:  J Biol Chem       Date:  1971-03-10       Impact factor: 5.157

10.  The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.

Authors:  K Weber; M Osborn
Journal:  J Biol Chem       Date:  1969-08-25       Impact factor: 5.157
  10 in total
  11 in total

1.  Expression and immunogenicity of a mutant diphtheria toxin molecule, CRM(197), and its fragments in Salmonella typhi vaccine strain CVD 908-htrA.

Authors:  N Orr; J E Galen; M M Levine
Journal:  Infect Immun       Date:  1999-08       Impact factor: 3.441

Review 2.  Diphtheria toxin: mode of action and structure.

Authors:  R J Collier
Journal:  Bacteriol Rev       Date:  1975-03

3.  Monoclonal B-cell response to diphtheria toxoid: evidence for cross-reactive epitopes.

Authors:  B Autran; F Triebel; M Viguier; M Jolivet; P Falmagne; P Debre
Journal:  Immunology       Date:  1987-04       Impact factor: 7.397

4.  Immunochemical studies of diphtherial toxin and related nontoxic mutant proteins.

Authors:  S J Cryz; S L Welkos; R K Holmes
Journal:  Infect Immun       Date:  1980-12       Impact factor: 3.441

5.  Population studies of diphtheria immunity using antitoxin radioimmunoassay.

Authors:  M A Menser; J R Hudson
Journal:  J Hyg (Lond)       Date:  1984-02

6.  Antigenic relationships on the diphtheria toxin molecule: antitoxin versus antitoxoid.

Authors:  M B Rittenberg; C T Pinney; B H Iglewski
Journal:  Infect Immun       Date:  1976-07       Impact factor: 3.441

7.  Quantitative assay of diphtherial toxin and of immunologically cross-reacting proteins by reversed passive hemagglutination.

Authors:  R K Holmes; R B Perlow
Journal:  Infect Immun       Date:  1975-12       Impact factor: 3.441

8.  Analysis of human anti-diphtheria antibodies by isoelectric focusing: evidence for restricted clonal heterogeneity of anti-fragment A antibodies.

Authors:  C D Morrow; E M Macy; R H Stevens
Journal:  Infect Immun       Date:  1981-03       Impact factor: 3.441

9.  Expression and purification of truncated diphtheria toxin, DT386, in Escherichia coli: An attempt for production of a new vaccine against diphtheria.

Authors:  Fatemeh Shafiee; Mohammad Rabbani; Mahdi Behdani; Ali Jahanian-Najafabadi
Journal:  Res Pharm Sci       Date:  2016-10

10.  Effect of formalin toxoiding on Pseudomonas aeruginosa toxin A: biological, chemical, and immunochemical studies.

Authors:  S J Cryz; R L Friedman; O R Pavlovskis; B H Iglewski
Journal:  Infect Immun       Date:  1981-05       Impact factor: 3.609
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