Literature DB >> 10417208

Expression and immunogenicity of a mutant diphtheria toxin molecule, CRM(197), and its fragments in Salmonella typhi vaccine strain CVD 908-htrA.

N Orr1, J E Galen, M M Levine.   

Abstract

Mutant diphtheria toxin molecule CRM(197) and fragments thereof were expressed in attenuated Salmonella typhi CVD 908-htrA, and the constructs were tested for their ability to induce serum antitoxin. Initially, expressed proteins were insoluble, and the constructs failed to induce neutralizing antitoxin. Soluble CRM(197) was expressed at low levels by utilizing the hemolysin A secretion system from Escherichia coli.

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Year:  1999        PMID： 10417208      PMCID： PMC96741     

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  24 in total

1.  Structure-function analyses of diphtheria toxin by use of monoclonal antibodies.

Authors:  J M Rolf; L Eidels
Journal:  Infect Immun       Date:  1993-03       Impact factor: 3.441

2.  Expression and immunogenicity of pertussis toxin S1 subunit-tetanus toxin fragment C fusions in Salmonella typhi vaccine strain CVD 908.

Authors:  E M Barry; O Gomez-Duarte; S Chatfield; R Rappuoli; M Pizza; G Losonsky; J Galen; M M Levine
Journal:  Infect Immun       Date:  1996-10       Impact factor: 3.441

3.  A murine model of intranasal immunization to assess the immunogenicity of attenuated Salmonella typhi live vector vaccines in stimulating serum antibody responses to expressed foreign antigens.

Authors:  J E Galen; O G Gomez-Duarte; G A Losonsky; J L Halpern; C S Lauderbaugh; S Kaintuck; M K Reymann; M M Levine
Journal:  Vaccine       Date:  1997 Apr-May       Impact factor: 3.641

4.  Urea/DTT solubilization of a recombinant Taenia ovis antigen, 45W, expressed as a GST fusion protein results in enhanced protective immune response to the 45W moiety.

Authors:  J S Rothel; P R Wood; H F Seow; M W Lightowlers
Journal:  Vaccine       Date:  1997-04       Impact factor: 3.641

Review 5.  Attenuated Salmonella as live oral vaccines against typhoid fever and as live vectors.

Authors:  M M Levine; J Galen; E Barry; F Noriega; S Chatfield; M Sztein; G Dougan; C Tacket
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6.  Safety of live oral Salmonella typhi vaccine strains with deletions in htrA and aroC aroD and immune response in humans.

Authors:  C O Tacket; M B Sztein; G A Losonsky; S S Wasserman; J P Nataro; R Edelman; D Pickard; G Dougan; S N Chatfield; M M Levine
Journal:  Infect Immun       Date:  1997-02       Impact factor: 3.441

7.  Superior efficacy of secreted over somatic antigen display in recombinant Salmonella vaccine induced protection against listeriosis.

Authors:  J Hess; I Gentschev; D Miko; M Welzel; C Ladel; W Goebel; S H Kaufmann
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Review 8.  Strategies for achieving high-level expression of genes in Escherichia coli.

Authors:  S C Makrides
Journal:  Microbiol Rev       Date:  1996-09

9.  Construction, expression, and immunogenicity of the Schistosoma mansoni P28 glutathione S-transferase as a genetic fusion to tetanus toxin fragment C in a live Aro attenuated vaccine strain of Salmonella.

Authors:  C M Khan; B Villarreal-Ramos; R J Pierce; G Riveau; R Demarco de Hormaeche; H McNeill; T Ali; N Fairweather; S Chatfield; A Capron
Journal:  Proc Natl Acad Sci U S A       Date:  1994-11-08       Impact factor: 11.205

10.  Expression of fragment C of tetanus toxin fused to a carboxyl-terminal fragment of diphtheria toxin in Salmonella typhi CVD 908 vaccine strain.

Authors:  O G Gómez-Duarte; J Galen; S N Chatfield; R Rappuoli; L Eidels; M M Levine
Journal:  Vaccine       Date:  1995-11       Impact factor: 3.641
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  12 in total

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3.  Induction of neutralizing antibodies against diphtheria toxin by priming with recombinant Mycobacterium bovis BCG expressing CRM(197), a mutant diphtheria toxin.

Authors:  E N Miyaji; R P Mazzantini; W O Dias; A L Nascimento; R Marcovistz; D S Matos; I Raw; N Winter; B Gicquel; R Rappuoli; L C Leite
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4.  In vivo characterization of the murine intranasal model for assessing the immunogenicity of attenuated Salmonella enterica serovar Typhi strains as live mucosal vaccines and as live vectors.

Authors:  T E Pickett; M F Pasetti; J E Galen; M B Sztein; M M Levine
Journal:  Infect Immun       Date:  2000-01       Impact factor: 3.441

5.  Adaptation of the endogenous Salmonella enterica serovar Typhi clyA-encoded hemolysin for antigen export enhances the immunogenicity of anthrax protective antigen domain 4 expressed by the attenuated live-vector vaccine strain CVD 908-htrA.

Authors:  James E Galen; Licheng Zhao; Magaly Chinchilla; Jin Yuan Wang; Marcela F Pasetti; Jeffrey Green; Myron M Levine
Journal:  Infect Immun       Date:  2004-12       Impact factor: 3.441

6.  Expression and immunogenicity of a recombinant diphtheria toxin fragment A in Streptococcus gordonii.

Authors:  Chiang W Lee; Song F Lee; Scott A Halperin
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7.  Expression, extracellular secretion, and immunogenicity of the Plasmodium falciparum sporozoite surface protein 2 in Salmonella vaccine strains.

Authors:  O G Gómez-Duarte; M F Pasetti; A Santiago; M B Sztein; S L Hoffman; M M Levine
Journal:  Infect Immun       Date:  2001-02       Impact factor: 3.441

Review 8.  Plant-based oral vaccines: results of human trials.

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9.  Salmonella enterica serovar typhimurium expressing a chromosomally integrated copy of the Bacillus anthracis protective antigen gene protects mice against an anthrax spore challenge.

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Journal:  Infect Immun       Date:  2003-07       Impact factor: 3.441

10.  Tunable Lipidoid-Telodendrimer Hybrid Nanoparticles for Intracellular Protein Delivery in Brain Tumor Treatment.

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