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Literature DB >> 4632133

Effect of anti-cord factor antibody on experimental tuberculosis in mice.

Abstract

Either active immunization with trehalose-6, 6'-dimycolate (cord factor)-methylated bovine serum albumin complex or passive transfer of rabbit anti-cord factor serum induced in mice an enhanced resistance against infection with virulent human Mycobacterium tuberculosis. This suggests that the anti-cord factor antibody exerts an infection-protecting effect by neutralizing the toxic action of cord factor during the course of living virulent infection with tubercle bacilli. The protective effect of active immunization with cord factor-methylated bovine serum albumin complex and of anti-cord factor serum was found to be specific for the tuberculous infection among a number of experimental infections in mice with a variety of cytopathogenic microorganisms tested.

Entities: Chemical Disease Species

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Year: 1973 PMID： 4632133 PMCID： PMC422632 DOI： 10.1128/iai.7.1.14-21.1973

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

16 in total

1. Biologic and biochemical activities of cord factor; with special reference to its role in the virulence of tubercle bacilli.

Authors: M KATO; K MIKI; K MATSUNAGA; Y YAMAMURA
Journal: Am Rev Tuberc Date: 1958-03

2. Site II-specific inhibition of mitochondria oxidative phosphorylation by trehalose-6,6'-dimycolate (cord factor) of Mycobacterium tuberculosis.

Authors: M Kato
Journal: Arch Biochem Biophys Date: 1970-10 Impact factor: 4.013

3. Studies of a biochemical lesion in experimental tuberculosis in mice. X. Mitochondrial swelling induced by cord factor in vivo and accompanying biochemical change.

Authors: M Kato; K Fukushi
Journal: Am Rev Respir Dis Date: 1969-07

4. Studies of a biochemical lesion in experimental tuberculosis in mice. XI. Mitochondrial swelling induced by cord factor in vitro.

Authors: M Kato
Journal: Am Rev Respir Dis Date: 1969-07

5. Immune response to sheep red blood cells in mice pretreated with mycobacterial fractions.

Authors: A Bekierkunst; E Yarkoni; I Flechner; S Morecki; E Vilkas; E Lederer
Journal: Infect Immun Date: 1971-09 Impact factor: 3.441

6. Cellular reaction in the footpad and draining lymph nodes of mice induced by mycobacterial fractions and BCG bacilli.

Authors: A Bekierkunst; I S Levij; E Yarkoni; E Vilkas; E Lederer
Journal: Infect Immun Date: 1971-09 Impact factor: 3.441

7. Suppression of urethan-induced lung adenomas in mice treated with trehalose-6,6-dimycolate (cord factor) and living bacillus Calmette Guérin.

Authors: A Bekierkunst; I S Levij; E Yarkoni
Journal: Science Date: 1971-12-17 Impact factor: 47.728

8. Immunochemical properties of anti-cord factor antibody.

Authors: M Kato
Journal: Infect Immun Date: 1973-01 Impact factor: 3.441

9. Granuloma formation induced in mice by chemically defined mycobacterial fractions.

Authors: A Bekierkunst; I S Levij; E Yarkoni; E Vilkas; A Adam; E Lederer
Journal: J Bacteriol Date: 1969-10 Impact factor: 3.490

10. Studies of a biochemical lesion in experimental tuberculosis in mice. VII. Structural and functional damage in mouse liver mitochondria under the toxic action of cord factor.

Authors: M Kato
Journal: Am Rev Respir Dis Date: 1968-08

8 in total

Review 1. Cell walls of Mycobacteria and related organisms; chemistry and immunostimulant properties.

Authors: E Lederer; A Adam; R Ciorbaru; J F Petit; J Wietzerbin
Journal: Mol Cell Biochem Date: 1975-05-30 Impact factor: 3.396

2. Cord factor (alpha,alpha-trehalose 6,6'-dimycolate) inhibits fusion between phospholipid vesicles.

Authors: B J Spargo; L M Crowe; T Ioneda; B L Beaman; J H Crowe
Journal: Proc Natl Acad Sci U S A Date: 1991-02-01 Impact factor: 11.205

Review 3. Mycobacterium.

Authors: L Barksdale; K S Kim
Journal: Bacteriol Rev Date: 1977-03