Literature DB >> 4631339

The effect of betahistine on gastric acid secretion and mucosal blood flow in conscious dogs.

B P Curwain, P Holton, J Spencer.   

Abstract

In 3 conscious dogs, betahistine (2-(2'-methyl aminoethyl pyridine)) (80 or 160mug kg(-1) min(-1)) increased acid secretion from Heidenhain pouches to 8.8% and 17.6% respectively of the maximal response to histamine. Betahistine also increased mucosal blood flow (radioactive aniline clearance). The ratio of mucosal blood flow to secretion was greater for betahistine than for histamine but the difference between betahistine and histamine was significant in only one of the dogs.

Entities:  

Mesh：

Substances：

Year:  1972        PMID： 4631339      PMCID： PMC1666342          DOI： 10.1111/j.1476-5381.1972.tb06881.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  11 in total

Review 1.  THE CIRCULATION OF THE STOMACH.

Authors:  E D JACOBSON
Journal:  Gastroenterology       Date:  1965-01       Impact factor: 22.682

2.  Clinical use of beta-2-pyridylalkylamines. I.

Authors:  B T HORTON; H VON LEDEN
Journal:  Proc Staff Meet Mayo Clin       Date:  1962-12-05

3.  Preliminary study of betahistine in chronic psychiatric patients with symptoms of arterio sclerosis cerebri.

Authors:  A H Esser; J Reis
Journal:  Curr Ther Res Clin Exp       Date:  1968-03

4.  Mechanisms relating gastric acid secretion and mucosal blood flow during gastrin and histamine stimulation.

Authors:  J D Reed; J R Smy
Journal:  J Physiol       Date:  1971-12       Impact factor: 5.182

5.  Double-blind evaluation of a new treatment for Ménière's syndrome.

Authors:  J C Elia
Journal:  JAMA       Date:  1966-04-11       Impact factor: 56.272

6.  Comparison of gastrin and histamine on gastric mucosal blood flow.

Authors:  E D Jacobson; A C Chang
Journal:  Proc Soc Exp Biol Med       Date:  1969-02

7.  Radioactive aniline clearance from canine gastric pouches for the measurement of gastric mucosal blood flow.

Authors:  B P Curwain; P Holton
Journal:  Br J Pharmacol       Date:  1971-02       Impact factor: 8.739

8.  Betahistine, its metabolites and vascular responses in the forelimb of the dog.

Authors:  H Konzett; R G Bost; F J Bowman; E R Bowman; H McKennis
Journal:  J Pharmacol Exp Ther       Date:  1971-07       Impact factor: 4.030

9.  Gastric secretion in relation to mucosal blood flow studied by a clearance technic.

Authors:  E D Jacobson; R H Linford; M I Grossman
Journal:  J Clin Invest       Date:  1966-01       Impact factor: 14.808

10.  The clinical use of beta-2-pyridylalkylamines. II. Treatment of histaminic cephalgia (Horton's headache) with a note on angina pectoris.

Authors:  B T HORTON
Journal:  Proc Staff Meet Mayo Clin       Date:  1962-12-19
View more
  4 in total

1.  Some studies of the action of betahistine at H1 and H2 receptors for histamine.

Authors:  P R Gater; S E Webber; G P Gui; C C Jordan; N A Hayes; J J Ashford; J C Foreman
Journal:  Agents Actions       Date:  1986-06

2.  Betahistine: a retrospective synopsis of safety data.

Authors:  Sabine Jeck-Thole; Wolfgang Wagner
Journal:  Drug Saf       Date:  2006       Impact factor: 5.606

Review 3.  Allergy and Ménière's disease.

Authors:  M Jennifer Derebery; Karen I Berliner
Journal:  Curr Allergy Asthma Rep       Date:  2007-11       Impact factor: 4.806

4.  Liberation of histamine by compound 48/80, tolazoline, betahistine and burimamide from isolated spontaneously beating guinea pig and rabbit atrial pairs.

Authors:  K E Light; M J Hughes
Journal:  Agents Actions       Date:  1979-06
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.