Literature DB >> 4622981

Influence of serum and calcium on the bactericidal activity of gentamicin and carbenicillin on Pseudomonas aeruginosa.

S D Davis, A Iannetta.   

Abstract

Because calcium was found to be antagonistic in vitro to the activity of colistin and polymyxin B on Pseudomonas aeruginosa, the effects of calcium and serum on gentamicin and carbenicillin were also examined. Serum was antagonistic to gentamicin in antibiotic tube dilution tests on five strains of P. aeruginosa. Serum was not antagonistic to carbenicillin in tube dilution tests. Physiologic concentrations of calcium antagonized the activity of gentamicin but not carbenicillin. The antagonism observed with gentamicin was less than that previously seen with colistin. The antagonistic effect of calcium and serum was removed by a chelating agent. Gentamicin and carbenicillin may be more active in vivo against P. aeruginosa than colistin or polymyxin B.

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Year:  1972        PMID： 4622981      PMCID： PMC380434          DOI： 10.1128/am.23.4.775-779.1972

Source DB:  PubMed          Journal:  Appl Microbiol        ISSN： 0003-6919


  12 in total

1.  The problem of synergism and antagonism of combined drugs.

Authors:  S LOEWE
Journal:  Arzneimittelforschung       Date:  1953-06

2.  Role of Multivalent Cations in the Organization, Structure, and Assembly of the Cell Wall of Pseudomonas aeruginosa.

Authors:  M A Asbell; R G Eagon
Journal:  J Bacteriol       Date:  1966-08       Impact factor: 3.490

3.  Chelation in experimental Pseudomonas keratitis.

Authors:  L A Wilson
Journal:  Br J Ophthalmol       Date:  1970-09       Impact factor: 4.638

4.  Carbenicillin and gentamycin in antibiotic combinations in vitro.

Authors:  R P Mouton; B Holtrigter
Journal:  Chemotherapy       Date:  1969       Impact factor: 2.544

5.  Combined action of carbenicillin and gentamicin on Pseudomonas aeruginosa in vitro.

Authors:  M Sonne; E Jawetz
Journal:  Appl Microbiol       Date:  1969-06

6.  Loss of sensitivity to EDTA by Pseudomonas aeruginosa grown under conditions of Mg-limitation.

Authors:  M R Brown; J Melling
Journal:  J Gen Microbiol       Date:  1968-12

7.  Paradoxical synergism and antagonism between serum and the antibacterial activity of colistin.

Authors:  S D Davis; A Iannetta; R J Wedgwood
Journal:  J Infect Dis       Date:  1971-04       Impact factor: 5.226

8.  Effect of ethylenediamine tetraacetate on the germicidal action of disinfectants against "Pseudomonas aeruginosa".

Authors:  G Reybrouck; H van de Voorde
Journal:  Acta Clin Belg       Date:  1969       Impact factor: 1.264

9.  New semi-synthetic penicillin active against Pseudomonas pyocyanea.

Authors:  P Acred; D M Brown; E T Knudsen; G N Rolinson; R Sutherland
Journal:  Nature       Date:  1967-07-01       Impact factor: 49.962

10.  Carbenicillin: activity in vitro and absorption and excretion in normal young men.

Authors:  C B Smith; M Finland
Journal:  Appl Microbiol       Date:  1968-11
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  9 in total

1.  Effect of calcium and magnesium ions on the susceptibility of Pseudomonas species to tetracycline, gentamicin polymyxin B, and carbenicillin.

Authors:  R F D'amato; C Thornsberry; C N Baker; L A Kirven
Journal:  Antimicrob Agents Chemother       Date:  1975-05       Impact factor: 5.191

2.  Potentiation of susceptibility to aminoglycosides by salicylate in Escherichia coli.

Authors:  M Aumercier; D M Murray; J L Rosner
Journal:  Antimicrob Agents Chemother       Date:  1990-05       Impact factor: 5.191

3.  Serum protein binding of the aminoglycoside antibiotics.

Authors:  R C Gordon; C Regamey; W M Kirby
Journal:  Antimicrob Agents Chemother       Date:  1972-09       Impact factor: 5.191

4.  Bactericidal activity of gentamicin against Enterococcus faecalis in vitro and in vivo.

Authors:  A Lefort; M Arthur; L Garry; C Carbon; P Courvalin; B Fantin
Journal:  Antimicrob Agents Chemother       Date:  2000-08       Impact factor: 5.191

5.  Effect of divalent cation concentrations on the antibiotic susceptibilities of nonfermenters other than Pseudomonas aeruginosa.

Authors:  R J Fass; J Barnishan
Journal:  Antimicrob Agents Chemother       Date:  1979-10       Impact factor: 5.191

6.  Chemically defined antimicrobial susceptibility test medium for Pseudomonas aeruginosa.

Authors:  J H Jorgensen; J C Lee; P M Jones
Journal:  Antimicrob Agents Chemother       Date:  1977-03       Impact factor: 5.191

7.  Dissociation between results of in vitro and in vivo antibiotic susceptibility tests for some strains of Pseudomonas aeruginosa.

Authors:  S D Davis
Journal:  Antimicrob Agents Chemother       Date:  1974-03       Impact factor: 5.191

8.  Antagonistic effect of calcium in serum on the activity of tobramycin against Pseudomonas.

Authors:  S D Davis; A Iannetta
Journal:  Antimicrob Agents Chemother       Date:  1972-06       Impact factor: 5.191

9.  Sisomicin: evaluation in vitro and comparison with gentamicin and tobramycin.

Authors:  C C Crowe; E Sanders
Journal:  Antimicrob Agents Chemother       Date:  1973-01       Impact factor: 5.191
  9 in total

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