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Literature DB >> 4790560

Serum protein binding of the aminoglycoside antibiotics.

Abstract

The binding of four aminoglycoside antibiotics by human serum was investigated under controlled conditions of physiological pH and temperature, by means of an ultrafiltration technique. No serum binding was demonstrable for gentamicin, tobramycin, or kanamycin, whereas streptomycin was 35% bound. Previous conflicting studies are discussed, and some of the pharmacological implications are considered.

Entities: Chemical Species

Mesh：

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Year: 1972 PMID： 4790560 PMCID： PMC444293 DOI： 10.1128/AAC.2.3.214

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

17 in total

1. In vitro and pharmacological studies with kanamycin.

Authors: H WELCH; W W WRIGHT; H I WEINSTEIN; A W STAFFA
Journal: Ann N Y Acad Sci Date: 1958-09-30 Impact factor: 5.691

Review 2. Antiobiotics in renal failure.

Authors: F O'Grady
Journal: Br Med Bull Date: 1971-05 Impact factor: 4.291

Review 3. The binding of drugs by plasma proteins.

Authors: M C Meyer; D E Guttman
Journal: J Pharm Sci Date: 1968-06 Impact factor: 3.534

4. Clinical pharmacology of the new penicillins. 1. The importance of serum protein binding in determining antimicrobial activity and concentration in serum.

Authors: C M Kunin
Journal: Clin Pharmacol Ther Date: 1966 Mar-Apr Impact factor: 6.875

5. Simplified, accurate method for antibiotic assay of clinical specimens.

Authors: J V Bennett; J L Brodie; E J Benner; W M Kirby
Journal: Appl Microbiol Date: 1966-03

6. [Pharmacological and therapeutic properties of gentamicin. Experimental studies on the effect level, excretion, stability and therapeutic indications].

Authors: P Naumann; W Auwärter
Journal: Arzneimittelforschung Date: 1968-09

7. Correlation of serum creatinine concentration and gentamicin half-life.

Authors: R E Cutler; A M Gyselynck; W P Fleet; A W Forrey
Journal: JAMA Date: 1972-02-21 Impact factor: 56.272

8. Pharmacology of gentamicin in man.

Authors: L J Riff; G G Jackson
Journal: J Infect Dis Date: 1971-12 Impact factor: 5.226

9. Pharmacokinetics of gentamicin: distribution and plasma and renal clearance.

Authors: A M Gyselynck; A Forrey; R Cutler
Journal: J Infect Dis Date: 1971-12 Impact factor: 5.226

10. Activity of gentamicin against Pseudomonas and hospital Staphylococci.

Authors: M Barber; P M Waterworth
Journal: Br Med J Date: 1966-01-22

44 in total

1. The prophylactic use of antibiotics in cell culture.

Authors: I Kuhlmann
Journal: Cytotechnology Date: 1995-06 Impact factor: 2.058

2. Hemodialyzer clearances of gentamicin, kanamycin, tobramycin, amikacin, ethambutol, procainamide, and flucytosine, with a technique for planning therapy.

Authors: T G Christopher; A D Blair; A W Forrey; R E Cutler
Journal: J Pharmacokinet Biopharm Date: 1976-10

Serum protein binding of the aminoglycoside antibiotics.

1. In vitro and pharmacological studies with kanamycin.

Review 2. Antiobiotics in renal failure.

Review 3. The binding of drugs by plasma proteins.

4. Clinical pharmacology of the new penicillins. 1. The importance of serum protein binding in determining antimicrobial activity and concentration in serum.

5. Simplified, accurate method for antibiotic assay of clinical specimens.

6. [Pharmacological and therapeutic properties of gentamicin. Experimental studies on the effect level, excretion, stability and therapeutic indications].

7. Correlation of serum creatinine concentration and gentamicin half-life.

8. Pharmacology of gentamicin in man.

9. Pharmacokinetics of gentamicin: distribution and plasma and renal clearance.

10. Activity of gentamicin against Pseudomonas and hospital Staphylococci.

1. The prophylactic use of antibiotics in cell culture.

2. Hemodialyzer clearances of gentamicin, kanamycin, tobramycin, amikacin, ethambutol, procainamide, and flucytosine, with a technique for planning therapy.

3. The penetration of antibiotics into peritoneal fluid.

4. Antibiotic sensitivities in vitro of diverse spiroplasma strains associated with plants and insects.

5. Effect of peritoneal dialysis on serum levels of tobramycin and clindamycin.

Review 6. Antibiotic tissue penetration and its relevance: impact of tissue penetration on infection response.

7. Effects of divalent cations on binding of aminoglycoside antibiotics to human serum proteins and to bacteria.

8. Renal pharmacology of netilmicin.

9. Renal extraction of gentamicin in anesthetized dogs.

Review 10. Why monitor serum levels of gentamicin?