Literature DB >> 4618481

Biogenesis of mitchondria. Phospholipid synthesis in vitro by yeast mitochondrial and microsomal fractions.

G S Cobon, P D Crowfoot, A W Linnane.   

Abstract

The ability in vitro of yeast mitochondrial and microsomal fractions to synthesize lipid de novo was measured. The major phospholipids synthesized from sn-[2-(3)H]glycerol 3-phosphate by the two microsomal fractions were phosphatidylserine, phosphatidylinositol and phosphatidic acid. The mitochondrial fraction, which had a higher specific activity for total glycerolipid synthesis, synthesized phosphatidylglycerol, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine and phosphatidic acid, together with smaller amounts of neutral lipids and diphosphatidylglycerol. Phosphatidylcholine synthesis from both S-adenosyl[Me-(14)C]methionine and CDP-[Me-(14)C]choline appeared to be localized in the microsomal fraction.

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Year:  1974        PMID： 4618481      PMCID： PMC1168493          DOI： 10.1042/bj1440265

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  30 in total

1.  A rapid method of total lipid extraction and purification.

Authors:  E G BLIGH; W J DYER
Journal:  Can J Biochem Physiol       Date:  1959-08

2.  The biosynthesis of phosphatidylglycerol.

Authors:  J Y KIYASU; R A PIERINGER; H PAULUS; E P KENNEDY
Journal:  J Biol Chem       Date:  1963-07       Impact factor: 5.157

3.  Partial resolution of the enzymes catalyzing oxidative phosphorylation. I. Purification and properties of soluble dinitrophenol-stimulated adenosine triphosphatase.

Authors:  M E PULLMAN; H S PENEFSKY; A DATTA; E RACKER
Journal:  J Biol Chem       Date:  1960-11       Impact factor: 5.157

4.  The function of cytidine coenzymes in the biosynthesis of phospholipides.

Authors:  E P KENNEDY; S B WEISS
Journal:  J Biol Chem       Date:  1956-09       Impact factor: 5.157

5.  Biogenesis of mitochondria 34. The synergistic interaction of nuclear and mitocohondrial mutations to produce resistance to high levels of mikamycin in Saccharomyces cerevisiae.

Authors:  N Howell; P L Molloy; A W Linnane; H B Lukins
Journal:  Mol Gen Genet       Date:  1974

Review 6.  Biosynthesis of mitochondrial enzymes.

Authors:  A Tzagoloff; M S Rubin; M F Sierra
Journal:  Biochim Biophys Acta       Date:  1973-02-12

7.  Biogenesis of mitochondria. 19. The effects of unsaturated fatty acid depletion on the lipid composition and energy metabolism of a fatty acid desaturase mutant of Saccharomyces cerevisiae.

Authors:  J W Proudlock; J M Haslam; A W Linnane
Journal:  J Bioenerg       Date:  1971-12

8.  Biogenesis of mitochondria. The effects of physiological and genetic manipulation of Saccharomyces cerevisiae on the mitochondrial transport systems for tricarboxylate-cycle anions.

Authors:  M Perkins; J M Haslam; A W Linnane
Journal:  Biochem J       Date:  1973-08       Impact factor: 3.857

9.  Biogenesis of mitochondria. A requirement for mitochondrial protein synthesis for the formation of a normal adenine nucleotide transporter in yeast mitochondria.

Authors:  J M Haslam; M Perkins; A W Linnane
Journal:  Biochem J       Date:  1973-08       Impact factor: 3.857

10.  Studies on the content and organization of the respiratory enzymes of mitochondria.

Authors:  R W ESTABROOK; A HOLOWINSKY
Journal:  J Biophys Biochem Cytol       Date:  1961-01
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  27 in total

1.  Biogenesis of mitochondria 36, The genetic and biochemical analysis of a mitochondrially determined cold sensitive oligomycin resistant mutant of Saccharomyces cerevisiae with affected mitochondrial ATPase assembly.

Authors:  M K Trembath; B C Monk; G M Kellerman; A W Linnane
Journal:  Mol Gen Genet       Date:  1975-11-03

2.  Phospholipid metabolism in plant mitochondria: submitochondrial sites of synthesis.

Authors:  S A Sparace; T S Moore
Journal:  Plant Physiol       Date:  1979-05       Impact factor: 8.340

3.  Biogenesis of mitochondria: defective yeast H+-ATPase assembled in the absence of mitochondrial protein synthesis is membrane associated.

Authors:  J M Orian; R G Hadikusumo; S Marzuki; A W Linnane
Journal:  J Bioenerg Biomembr       Date:  1984-12       Impact factor: 2.945

Review 4.  Genetic regulation of phospholipid biosynthesis in Saccharomyces cerevisiae.

Authors:  M L Greenberg; J M Lopes
Journal:  Microbiol Rev       Date:  1996-03

Review 5.  Lipids of yeasts.

Authors:  J B Rattray; A Schibeci; D K Kidby
Journal:  Bacteriol Rev       Date:  1975-09

Review 6.  Lipid transport in microorganisms.

Authors:  G Daum; F Paltauf
Journal:  Experientia       Date:  1990-06-15

7.  Enzymatic detection of phospholipid biosynthetic enzymes after electroblotting.

Authors:  M A Poole; A S Fischl; G M Carman
Journal:  J Bacteriol       Date:  1985-02       Impact factor: 3.490

8.  Transmembrane ferricyanide reduction by cells of the yeast Saccharomyces cerevisiae.

Authors:  F L Crane; H Roberts; A W Linnane; H Löw
Journal:  J Bioenerg Biomembr       Date:  1982-06       Impact factor: 2.945

9.  Replicative deoxyribonucleic acid synthesis in isolated mitochondria from Saccharomyces cerevisiae.

Authors:  J S Mattick; R M Hall
Journal:  J Bacteriol       Date:  1977-06       Impact factor: 3.490

10.  The in vivo incorporation of [32P]-labeled orthophosphate into pyrophosphatidic acid and other phospholipids of Cryptococcus neoformans through cell growth.

Authors:  T Itoh; H Kaneko
Journal:  Lipids       Date:  1977-10       Impact factor: 1.880
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