Literature DB >> 4607336

Variability in response to drugs.

M D Rawlins.   

Abstract

Variability in the response to drugs is due to three principal components-the disease, the responsiveness of tissues, and the concentration of the drug at its site of action (as reflected by its plasma concentration). The relative contributions of these components will differ not only for different drugs but also for different effects of the same drug. Rational drug therapy depends on knowledge of all three factors.

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Year:  1974        PMID： 4607336      PMCID： PMC1612144          DOI： 10.1136/bmj.4.5936.91

Source DB:  PubMed          Journal:  Br Med J        ISSN： 0007-1447


  40 in total

1.  HEREDITARY DIAPHORASE DEFICIENCY AND METHEMOGLOBINEMIA.

Authors:  M CAWEIN; C H BEHLEN; E J LAPPAT; J E COHN
Journal:  Arch Intern Med       Date:  1964-04

2.  The effects of spironolactone and chlorthalidone on arterial pressure.

Authors:  W I CRANSTON; B E JUEL-JENSEN
Journal:  Lancet       Date:  1962-06-02       Impact factor: 79.321

3.  Clinical and electroencephalographic correlations with serum levels of diphenylhydanotin.

Authors:  F BUCHTHAL; O SVENSMARK; P J SCHILLER
Journal:  Arch Neurol       Date:  1960-06

4.  Tablet disintegration: possible link with biological availability of digoxin.

Authors:  V Manninen; J Melin; P Reissel
Journal:  Lancet       Date:  1972-02-26       Impact factor: 79.321

5.  Antiarrhythmic prophylaxis with procainamide in acute myocardial infarction.

Authors:  J Koch-Weser; S W Klein; L L Foo-Canto; J A Kastor; R W DeSanctis
Journal:  N Engl J Med       Date:  1969-12-04       Impact factor: 91.245

6.  Pharmacokinetics of theophylline. Application to adjustment of the clinical dose of aminophylline.

Authors:  J W Jenne; M S Wyze; F S Rood; F M MacDonald
Journal:  Clin Pharmacol Ther       Date:  1972 May-Jun       Impact factor: 6.875

7.  The polymorphic acetylation of dapsone in man.

Authors:  R Gelber; J H Peters; G R Gordon; A J Glazko; L Levy
Journal:  Clin Pharmacol Ther       Date:  1971 Mar-Apr       Impact factor: 6.875

8.  Prediction of drug oxidation rates in man: lack of correlation with serum gamma-glutamyl transpeptidase and urinary excretion of D-glucaric acid and 6 beta-hydroxycortisol.

Authors:  S E Smith; M D Rawlins
Journal:  Eur J Clin Pharmacol       Date:  1974       Impact factor: 2.953

9.  Studies on the metabolism of diphenylhydantoin (Dilantin).

Authors:  E W LOESER
Journal:  Neurology       Date:  1961-05       Impact factor: 9.910

10.  Everest MS: Measurement of digoxin in plasma and its use in diagnosis of digoxin intoxication.

Authors:  D G Grahame-Smith
Journal:  Br Med J       Date:  1969-02-01
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  3 in total

1.  Ethnicity and psychopharmacology.

Authors:  K M Lin; R E Poland; I M Lesser
Journal:  Cult Med Psychiatry       Date:  1986-06

2.  Factors influencing blood concentrations of chlordiazepoxide: a use of multiple regression analysis.

Authors:  D J Greenblatt; J S Harmatz; D R Stanski; R I Shader; K Franke; J Koch-Weser
Journal:  Psychopharmacology (Berl)       Date:  1977-11-15       Impact factor: 4.530

3.  Liquid Biopsy Enables Quantification of the Abundance and Interindividual Variability of Hepatic Enzymes and Transporters.

Authors:  Brahim Achour; Zubida M Al-Majdoub; Agnieszka Grybos-Gajniak; Kristi Lea; Peter Kilford; Mian Zhang; David Knight; Jill Barber; Jeoffrey Schageman; Amin Rostami-Hodjegan
Journal:  Clin Pharmacol Ther       Date:  2020-11-25       Impact factor: 6.903
  3 in total

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