Literature DB >> 46054

Probable identification of an HL-A second-locus antigen associated with a high risk of nasopharyngeal carcinoma.

M J Simons, G B Wee, S H Chan, K Shanmugaratnam.   

Abstract

An HL-A antigen profile comprising an increased frequency of HL-A2 and undetectable second-locus antigen(s) in Chinese patients with nasopharyngeal carcinoma (N.P.C.) has been reported. To investigate whether the deficit of second-locus antigen(s) had a genetic basis, sera from parous women in Singapore were screened for anti HL-A activity corresponding to the second-locus "bland". A second-locus (Singapore-2) was identified which seems to be associated with a high risk of N.P.C.

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Year:  1975        PMID： 46054     DOI： 10.1016/s0140-6736(75)91433-6

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  12 in total

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Authors:  Hai-De Qin; Yin Yao Shugart; Jin-Xin Bei; Qing-Hua Pan; Lina Chen; Qi-Sheng Feng; Li-Zhen Chen; Wei Huang; Jian Jun Liu; Timothy J Jorgensen; Yi-Xin Zeng; Wei-Hua Jia
Journal:  Cancer Res       Date:  2011-03-02       Impact factor: 12.701

6.  The inter-locus recombinant HLA-B*4601 has high selectivity in peptide binding and functions characteristic of HLA-C.

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7.  HLA A2.1-restricted cytotoxic T cells recognizing a range of Epstein-Barr virus isolates through a defined epitope in latent membrane protein LMP2.

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