Literature DB >> 4597721

Turbidimetric bioassay for carbenicillin.

J P Stankewich, R P Upton.   

Abstract

A quantitative turbidimetric bioassay has been developed for carbenicillin with the use of a strain of Escherichia coli. The assay is relatively specific for carbenicillin and is not affected by 10% (wt/wt) benzylpenicillin. It has been demonstrated to be more precise than the plate diffusion assay. Since it is readily automated, it is also faster and less expensive. The influence of pH, time, and extent of growth on the assay has been evaluated.

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Year:  1973        PMID： 4597721      PMCID： PMC444416          DOI： 10.1128/AAC.3.3.364

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  7 in total

1.  Automated microbiological assay. I. Experiences in assaying ampicillin and carbenicillin.

Authors:  A Jones; G Palmer
Journal:  Analyst       Date:  1970-05       Impact factor: 4.616

2.  Development of quality control methodology for new drugs.

Authors:  R L Wagner
Journal:  Bull Parenter Drug Assoc       Date:  1972 Mar-Apr

3.  Laboratory studies with carbenicillin.

Authors: 
Journal:  Antimicrob Agents Chemother (Bethesda)       Date:  1968

4.  Procedures for the assay of carbenicillin in body fluids.

Authors:  J Burnett; R Sutherland
Journal:  Appl Microbiol       Date:  1970-02

5.  Automated system for analytical microbiology. II. Construction of system and evaluation of antibiotics and vitamins.

Authors:  N R Kuzel; F W Kavanagh
Journal:  J Pharm Sci       Date:  1971-05       Impact factor: 3.534

6.  In vitro action of carbenicillin against bacteria isolated from clinical material.

Authors:  H D Isenberg; M Siegel
Journal:  Appl Microbiol       Date:  1969-09

7.  Carbenicillin: activity in vitro and absorption and excretion in normal young men.

Authors:  C B Smith; M Finland
Journal:  Appl Microbiol       Date:  1968-11
  7 in total
  1 in total

1.  Semiautomated turbidimetric microbiological assay for determination of cefazolin.

Authors:  D Pitkin; P Actor; W Holl; A Post; J A Weisbach
Journal:  Antimicrob Agents Chemother       Date:  1974-03       Impact factor: 5.191
  1 in total

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