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Literature DB >> 458433

Distribution of PNMT and epinephrine in the medulla oblongata of normotensive and spontaneous hypertensive rats.

J Y Lew, F Hata, A Sauter, Y Baba, J Engel, M Goldstein.

Abstract

The distribution of the Epinephrine forming enzyme (PNMT) activity and Epinephrine (E) levels was investigated in the medulla oblongata of spontaneous hypertensive rats (SH-rats) and in two normotensive strains, namely Wistar Kyoto rats (WK-rats) and Wistar rats. The PNMT activity increases progressively from the caudal to rostral parts in the C1 and C2 regions of the medulla oblongata. The enzyme activity and the E levels are in all parts of the C1 and C2 regions higher in Wistar rats than in WK-rats. The PNMT activity in all parts of the C2 region (with the exception of the caudal region), and in the middle part of the C1 region is higher in SH-rats than in WK-rats. The E levels in the SH-rats are higher than in WK-rats in the mediocaudal parts of the C2 and C1 regions.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 1979 PMID： 458433 DOI： 10.1007/bf01250326

Source DB: PubMed Journal: J Neural Transm Impact factor: 3.575

11 in total

1. Effect of phenylethanolamine N-methyltransferase and dopamine-beta-hydroxylase inhibition on epinephrine levels in the brain.

Authors: A M Sauter; J Y Lew; Y Baba; M Goldstein
Journal: Life Sci Date: 1977-07-15 Impact factor: 5.037

2. Simultaneous radioenzymatic determination of plasma and tissue adrenaline, noradrenaline and dopamine within the femtomole range.

Authors: M Da Prada
Journal: Life Sci Date: 1976-10-15 Impact factor: 5.037

3. Catecholamine content of individual brain regions of spontaneously hypertensive rats (SH-rats).

Authors: D H Versteeg; M Palkovits; J Van der Gugten; H L Wijnen; G W Smeets; W de Jong
Journal: Brain Res Date: 1976-08-13 Impact factor: 3.252

4. Localisation of phenylethanolamine N-methyl transferase in the rat brain nuclei.

Authors: J M Saavedra; M Palkovits; M J Brownstein; J Axelrod
Journal: Nature Date: 1974-04-19 Impact factor: 49.962

5. Inhibition of transmethylations of biogenic amines by S-adenosylhomocysteine. Enhancement of transmethylation by adenosylhomocysteinase.

Authors: T Deguchi; J Barchas
Journal: J Biol Chem Date: 1971-05-25 Impact factor: 5.157

6. Possible involvement of central adrenaline neurons in vasomotor and respiratory control. Studies with clonidine and its interactions with piperoxane and yohimbine.

Authors: P Bolme; H Corrodi; K Fuxe; T Hökfelt; P Lidbrink; M Goldstein
Journal: Eur J Pharmacol Date: 1974-09 Impact factor: 4.432

7. Increased adrenaline content of individual nuclei of the hypothalamus and the medulla oblongata of genetically hypertensive ralamus and the medulla oblongata of genetically hypertensive rats.

Authors: H J Wijnen; D H Versteeg; M Palkovits; W De Jong
Journal: Brain Res Date: 1977-10-21 Impact factor: 3.252

1. Involvement of central alpha- and beta-adrenoceptors in the pressor response to electrical stimulation of the rostral ventrolateral medulla in rats.

Authors: C Ward-Routledge; P Marshall; C A Marsden
Journal: Br J Pharmacol Date: 1988-06 Impact factor: 8.739

1 in total