| Literature DB >> 1246633 |
J M Saavedra, H Grobecker, J Axelrod.
Abstract
The adrenaline-forming enzyme (phenylethanolamine N-methyltransferase) was elevated in the A1 and A2 regions of the brainstem of 4-week-old spontaneously (genetic) hypertensive rats and in the A1 region of adult experimentally (deoxycorticosterone acetate and sodium chloride) hypertensive rats. The administration of a phenylethanolamine N-methyltransferase inhibitor to experimentally hypertensive animals caused a reduction of the elevated blood pressure to normal values. These results implicate adrenaline-containing neurons in the brainstem in the development of hypertension.Entities:
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Year: 1976 PMID： 1246633 DOI： 10.1126/science.1246633
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728