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Literature DB >> 4579822

Mutagenic effect of temperature-sensitive mutants of gene 42 (dCMP hydroxymethylase) of bacteriophage T4.

Abstract

Certain temperature-sensitive mutants of gene 42 of bacteriophage T4 increase the reversion rates of some rII mutants in the same genome by about 4 to 10 times. This effect was usually found at 34 C, an intermediate permissive temperature, but not at 28 C.

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Year: 1973 PMID： 4579822 PMCID： PMC355246

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

8 in total

1. Studies on the biochemical basis of spontaneous mutation. I. A comparison of the deoxyribonucleic acid polymerases of mutator, antimutator, and wild type strains of bacteriophage T4.

Authors: N Muzyczka; R L Poland; M J Bessman
Journal: J Biol Chem Date: 1972-11-25 Impact factor: 5.157

2. Evidence for a dual role for the bacteriophage T4-induced deoxycytidine triphosphate nucleotidohydrolase.

Authors: H R Warner; J E Barnes
Journal: Proc Natl Acad Sci U S A Date: 1966-10 Impact factor: 11.205

3. Evidence for a possible direct role of dCMP hydroxymethylase in T4 phage DNA synthesis.

Authors: C S Chiu; G R Greenberg
Journal: Cold Spring Harb Symp Quant Biol Date: 1968

4. On the role of DNA polymerase in base selection.

Authors: J F Speyer; J D Karam; A B Lenny
Journal: Cold Spring Harb Symp Quant Biol Date: 1966

5. Antimutagenic DNA polymerases of bacteriophage T4.

Authors: J W Drake; E F Allen
Journal: Cold Spring Harb Symp Quant Biol Date: 1968

6. The structural gene for deoxyribonucleic acid polymerase in bacteriophages T4 and T5.

Authors: A De Waard; A V Paul; I R Lehman
Journal: Proc Natl Acad Sci U S A Date: 1965-10 Impact factor: 11.205

7. Mutagenic DNA polymerase.

Authors: J F Speyer
Journal: Biochem Biophys Res Commun Date: 1965-10-08 Impact factor: 3.575

8. Reversion of frameshift mutations stimulated by lesions in early function genes of bacteriophage T4.

Authors: H Bernstein
Journal: J Virol Date: 1971-04 Impact factor: 5.103

8 in total

6 in total

1. Analysis of mutagenesis induced by a thermolabile T4 phage deoxycytidylate hydroxymethylase suggests localized deoxyribonucleotide pool imbalance.

Authors: J P Ji; C K Mathews
Journal: Mol Gen Genet Date: 1991-04

Mutagenic effect of temperature-sensitive mutants of gene 42 (dCMP hydroxymethylase) of bacteriophage T4.

1. Studies on the biochemical basis of spontaneous mutation. I. A comparison of the deoxyribonucleic acid polymerases of mutator, antimutator, and wild type strains of bacteriophage T4.

2. Evidence for a dual role for the bacteriophage T4-induced deoxycytidine triphosphate nucleotidohydrolase.

3. Evidence for a possible direct role of dCMP hydroxymethylase in T4 phage DNA synthesis.

4. On the role of DNA polymerase in base selection.

5. Antimutagenic DNA polymerases of bacteriophage T4.

6. The structural gene for deoxyribonucleic acid polymerase in bacteriophages T4 and T5.

7. Mutagenic DNA polymerase.

8. Reversion of frameshift mutations stimulated by lesions in early function genes of bacteriophage T4.

1. Analysis of mutagenesis induced by a thermolabile T4 phage deoxycytidylate hydroxymethylase suggests localized deoxyribonucleotide pool imbalance.

Review 2. The cell-bag of enzymes or network of channels?

3. Reversion of bacteriophage T4rII mutants by high levels of pyrimidine deoxyribonucleosides.

4. Mutator mutations in bacteriophage T4 gene 32 (DNA unwinding protein).

5. Mutator and antimutator phenotypes of suppressed amber mutants in genes 32, 41, 44, 45, and 62 in bacteriophage T4.

6. Yeast gene CDC8 encodes thymidylate kinase and is complemented by herpes thymidine kinase gene TK.