| Literature DB >> 4180576 |
R E Spitzer, E H Vallota, J Forristal, E Sudora, A Stitzel, N C Davis, C D West.
Abstract
The serums of patients with hypocomplementemic glomerulonephritis contain a substance that combines with a normal serum cofactor in the presence of magnesium ion to specifically cleave the third component of complement. This lysis of C'3 is 80 to 90 percent complete in 20 minutes at 37 degrees C and pH 7. Neither the nephritic factor nor its cofactor is identifiable with the complement system.Entities:
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Year: 1969 PMID: 4180576 DOI: 10.1126/science.164.3878.436
Source DB: PubMed Journal: Science ISSN: 0036-8075 Impact factor: 47.728