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Literature DB >> 4579012

A genetic method for determining the order of events in a biological pathway.

Abstract

We describe the application of a simple genetic test that indicates the order of events in a morphogenic or biochemical pathway. The test uses temperature-sensitive (ts) and cold-sensitive (cs) mutants, and it orders the times at which the ts and cs defects are expressed.

Entities: Chemical

Mesh：

Year: 1973 PMID： 4579012 PMCID： PMC433662 DOI： 10.1073/pnas.70.7.2046

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

21 in total

1. TEMPERATURE-SENSITIVE MUTANTS OF BACTERIOPHAGE T4D: THEIR ISOLATION AND GENETIC CHARACTERIZATION.

Authors: R S EDGAR; I LIELAUSIS
Journal: Genetics Date: 1964-04 Impact factor: 4.562

2. THE PROPERTIES OF REPRESSOR AND THE KINETICS OF ITS ACTION.

Authors: J R SADLER; A NOVICK
Journal: J Mol Biol Date: 1965-06 Impact factor: 5.469

3. Genetics of bacteriophage P22. II. Gene order and gene function.

Authors: D Botstein; R K Chan; C H Waddell
Journal: Virology Date: 1972-07 Impact factor: 3.616

4. Reversible inactivation of T4 ts DNA polymerase mutants in vivo.

Authors: J D Karam; J F Speyer
Journal: Virology Date: 1970-09 Impact factor: 3.616

5. A new class of temperature conditional lethal mutants of bacteriophage T4D.

Authors: P D Scotti
Journal: Mutat Res Date: 1968 Jul-Aug Impact factor: 2.433

6. Cold-sensitive mutations in Salmonella typhimurium which affect ribosome synthesis.

Authors: P C Tai; D P Kessler; J Ingraham
Journal: J Bacteriol Date: 1969-03 Impact factor: 3.490

7. Cold-sensitive mutants of Escherichia coli resulting from increased feedback inhibition.

Authors: G A O'Donovan; J L Ingraham
Journal: Proc Natl Acad Sci U S A Date: 1965-08 Impact factor: 11.205

8. The behavior of temperature-sensitive T4 DNA polymerase mutants in temperature shift experiments.

Authors: P D Scotti
Journal: Virology Date: 1971-02 Impact factor: 3.616

9. Cold-sensitive mutants of bacteriophage lambda.

Authors: J H Cox; H B Strack
Journal: Genetics Date: 1971-01 Impact factor: 4.562

10. Macromolecule synthesis in temperature-sensitive mutants of yeast.

Authors: L H Hartwell
Journal: J Bacteriol Date: 1967-05 Impact factor: 3.490

43 in total

1. Conditional-lethal mutations that suppress genetic defects in morphogenesis by altering structural proteins.

Authors: J Jarvik; D Botstein
Journal: Proc Natl Acad Sci U S A Date: 1975-07 Impact factor: 11.205

Review 2. Genetic aspects of bacterial endospore formation.

Authors: P J Piggot; J G Coote
Journal: Bacteriol Rev Date: 1976-12

Review 3. Old, new, and widely true: The bacteriophage T4 DNA packaging mechanism.

Authors: Lindsay W Black
Journal: Virology Date: 2015-02-27 Impact factor: 3.616

Review 4. Functional and genomic context in pathway analysis of GWAS data.

Authors: Michael A Mooney; Joel T Nigg; Shannon K McWeeney; Beth Wilmot
Journal: Trends Genet Date: 2014-08-22 Impact factor: 11.639

5. The Ess1 prolyl isomerase is required for growth and morphogenetic switching in Candida albicans.

Authors: Gina Devasahayam; Vishnu Chaturvedi; Steven D Hanes
Journal: Genetics Date: 2002-01 Impact factor: 4.562

6. The large subunit of replication factor C (Rfc1p/Cdc44p) is required for DNA replication and DNA repair in Saccharomyces cerevisiae.

Authors: M A McAlear; K M Tuffo; C Holm
Journal: Genetics Date: 1996-01 Impact factor: 4.562