Literature DB >> 4568302

Stimulation of IgG antibody response in vitro by T cell-replacing factor.

A Schimpl, E Wecker.   

Abstract

A soluble factor (TRF) produced by mixtures of allogeneic mouse spleen, lymph node, and thymus cells functionally replaces T cells in a primary IgM antibody response to sheep blood cells in vitro. It is now shown that TRF can also reconstitute an IgG antibody response in T cell-deprived spleen cultures derived from preimmunized mice. The optimal time of addition and the amount of TRF required differ between primary and secondary in vitro systems.

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Year:  1973        PMID： 4568302      PMCID： PMC2139499          DOI： 10.1084/jem.137.2.547

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  11 in total

1.  Carrier function in anti-hapten antibody responses. 3. Stimulation of antibody synthesis and facilitation of hapten-specific secondary antibody responses by graft-versus-host reactions.

Authors:  D H Katz; W E Paul; E A Goidl; B Benacerraf
Journal:  J Exp Med       Date:  1971-02-01       Impact factor: 14.307

2.  Immunological B memory in thymus deprived mice.

Authors:  G E Roelants; B A Askonas
Journal:  Nat New Biol       Date:  1972-09-13

3.  Cell interaction in an immune response in vitro: requirement for theta-carrying cells.

Authors:  E L Chan; R I Mishell; G F Mitchell
Journal:  Science       Date:  1970-12-11       Impact factor: 47.728

4.  Inhibition of in vitro immune response by treatment of spleen cell suspensions with anti-theta serum.

Authors:  A Schimpl; E Wecker
Journal:  Nature       Date:  1970-06-27       Impact factor: 49.962

5.  The use of concanavalin A for distinguishing IgM from IgG antibody-producing cells.

Authors:  A A Nordin; H Cosenza; W Hopkins
Journal:  J Immunol       Date:  1969-10       Impact factor: 5.422

6.  Absence of thymus in a mouse mutant.

Authors:  E M Pantelouris
Journal:  Nature       Date:  1968-01-27       Impact factor: 49.962

7.  Thymus dependence of antibody response: variation with dose of antigen and class of antibody.

Authors:  R B Taylor; H H Wortis
Journal:  Nature       Date:  1968-11-30       Impact factor: 49.962

8.  New indicator of histocompatibility differences in vitro.

Authors:  A Ekpaha-Mensah; J C Kennedy
Journal:  Nat New Biol       Date:  1971-10-06

9.  Plaque Formation in Agar by Single Antibody-Producing Cells.

Authors:  N K Jerne; A A Nordin
Journal:  Science       Date:  1963-04-26       Impact factor: 47.728

10.  Cell interactions in the immune response in vitro. IV. Comparison of the effects of antigen-specific and allogeneic thymus-derived cell factors.

Authors:  M Feldmann; A Basten
Journal:  J Exp Med       Date:  1972-10-01       Impact factor: 14.307
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  21 in total

1.  Patterns of B-lymphocyte gene expression elicited by lipopolysaccharide mitogen.

Authors:  G Janossy; J Snajdr; M Simak-Ellis
Journal:  Immunology       Date:  1976-06       Impact factor: 7.397

2.  Hyperactive T-cell function in young NZB mice; increased proliferative responses to allogenic cells.

Authors:  D W Palmer; M J Dauphinée; E Murphy; N Talal
Journal:  Clin Exp Immunol       Date:  1976-03       Impact factor: 4.330

3.  Quantitative estimations of five classes of immunoglobulin in inbred mouse strains.

Authors:  S Natsuume-Sakai; K Motonishi; S Migita
Journal:  Immunology       Date:  1977-06       Impact factor: 7.397

4.  Non-specific factor replaces T cells in an IgG response to soluble antigens.

Authors:  J R North; J T Kemshead; B A Askonas
Journal:  Immunology       Date:  1977-09       Impact factor: 7.397

5.  Functional maturation of neonatal spleen cells.

Authors:  R Bösing-Schneider
Journal:  Immunology       Date:  1979-03       Impact factor: 7.397

6.  Conditions for the development of IgM- and IgG-antibody-secreting cells from primed mouse splenocytes in vitro.

Authors:  R M Maizels; D W Dresser
Journal:  Immunology       Date:  1977-05       Impact factor: 7.397

7.  B-memory cells can be stimulated by antigen in vitro to become IgG antibody-secreting cells.

Authors:  J R North; R M Maizels
Journal:  Immunology       Date:  1977-05       Impact factor: 7.397

8.  Effects of the B-cell activators lipid A and dextran sulphate on the antibody response to sheep red blood cells in piglets.

Authors:  J G Thalhammer; W Stöckl; C Reyero
Journal:  Immunology       Date:  1978-11       Impact factor: 7.397

9.  In vitro anamnestic immune responses and modulating factors.

Authors:  A B Stavitsky; A A Gerblich
Journal:  Mol Cell Biochem       Date:  1979-12-14       Impact factor: 3.396

10.  Immunoglobulin synthesis in vitro by lymphocytes from patients with immune deficiency: requirements for a special serum factor.

Authors:  P Wernet; F P Siegal; H Dickler; S Fu; H G Kunkel
Journal:  Proc Natl Acad Sci U S A       Date:  1974-02       Impact factor: 11.205
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