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Literature DB >> 133009

Hyperactive T-cell function in young NZB mice; increased proliferative responses to allogenic cells.

D W Palmer, M J Dauphinée, E Murphy, N Talal.

Abstract

The one-way mixed lymphocyte reaction was employed to study proliferative responses to antigens by mature, immunocompetent T cells from NZB mice 3 weeks to 4 months old. Compared to cells from control mice of the same H-2 type, thymus, spleen and lymph node cells from NZB mice were hyperactive in this response. The results are discussed in relation to possible effects of chronic stimulation by endogenous type C leukaemia virus upon differentiation of functional T cells or upon regulation by T cells of other T-cell functions, including augmentation of antibody responses.

Entities: Disease Gene Species

Mesh：

Substances：
Antigens

Year: 1976 PMID： 133009 PMCID： PMC1538388

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

24 in total

5. Lymphocyte classes in New Zealand mice. I. Ontogeny and mitogen responsiveness of thymocytes and thymus-derived lymphocytes.

Authors: J D Stobo; N Talal; W E Paul
Journal: J Immunol Date: 1972-10 Impact factor: 5.422

9. Immunologic properties of mouse thymus cells. Identification of T cell functions within a minor, low-density subpopulation.

Authors: S Konda; Y Nakao; R T Smith
Journal: J Exp Med Date: 1972-12-01 Impact factor: 14.307

10. Regulatory mechanisms in cell-mediated immune responses. I. Regulation of mixed lymphocyte reactions by alloantigen-activated thymus-derived lymphocytes.

Authors: S S Rich; R R Rich
Journal: J Exp Med Date: 1974-12-01 Impact factor: 14.307

2 in total

1. Hyper-responsiveness in NZB mice to the experimental induction of anti-red cell autoantibody.

Authors: A Cooke; J H Playfair
Journal: Clin Exp Immunol Date: 1977-03 Impact factor: 4.330

2. Primary in vitro cell-mediated lympholysis reaction of NZB mice against unmodified targets syngeneic at the major histocompatibility complex.

Authors: U Botzenhardt; J Klein; M Ziff
Journal: J Exp Med Date: 1978-05-01 Impact factor: 14.307

2 in total

Hyperactive T-cell function in young NZB mice; increased proliferative responses to allogenic cells.

1. Evidence for an abnormal microenvironment in the thymus of New Zealand black mice.

2. The effect of Freund's complete adjuvant on the cellular response in mice to sheep erythrocytes.

3. Cross-reactions between erythrocytes at the T-cell level.

Review 4. Autoimmunity and neoplasia. The possible role of C-type viruses.

5. Lymphocyte classes in New Zealand mice. I. Ontogeny and mitogen responsiveness of thymocytes and thymus-derived lymphocytes.

6. Lymphocyte subpopulations in NZB mice: deficit of thymus-dependent lymphocytes.

7. The stimulatory effect of tumor bearing upon the T- and B-cell subpopulations of the mouse spleen.

Review 8. Immunity to infection, allograft immunity and tumour immunity: parallels and contrasts.

9. Immunologic properties of mouse thymus cells. Identification of T cell functions within a minor, low-density subpopulation.

10. Regulatory mechanisms in cell-mediated immune responses. I. Regulation of mixed lymphocyte reactions by alloantigen-activated thymus-derived lymphocytes.

1. Hyper-responsiveness in NZB mice to the experimental induction of anti-red cell autoantibody.

2. Primary in vitro cell-mediated lympholysis reaction of NZB mice against unmodified targets syngeneic at the major histocompatibility complex.