Literature DB >> 4566459

Isolation of a mutant of Salmonella typhimurium dependent on D-arabinose-5-phosphate for growth and synthesis of 3-deoxy-D-mannoctulosonate (ketodeoxyoctonate).

P D Rick, M J Osborn.   

Abstract

A new type of auxotrophic mutant of Salmonella typhimurium has been isolated that is defective in the synthesis of the 3-deoxy-D-mannooctulosonate (ketodeoxyoctonate) region of the lipopolysaccharide and requires D-arabinose-5-phosphate for growth. Genetic and biochemical evidence indicated that the mutant defect was due to an altered ketodeoxyoctonate-8-phosphate synthetase with an apparent K(m) for D-arabinose-5-phosphate 35-fold higher than that of the parental enzyme. As a result of this enzymatic lesion, the mutant strain was dependent on exogenous D-arabinose-5-phosphate both for growth and for synthesis of a complete lipopolysaccharide.

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Year:  1972        PMID： 4566459      PMCID： PMC389865          DOI： 10.1073/pnas.69.12.3756

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  23 in total

1.  Biochemical studies on lipopolysaccharides of Salmonella R mutants. 6. Investigations on the structure of the lipid A component.

Authors:  J Gmeiner; O Lüderitz; O Westphal
Journal:  Eur J Biochem       Date:  1969-01

2.  Structure and biosynthesis of the cell wall lipopolysaccharide of Escherichia coli.

Authors:  E C Heath; R M Mayer; R D Edstrom; C A Beaudreau
Journal:  Ann N Y Acad Sci       Date:  1966-06-30       Impact factor: 5.691

3.  The biosynthesis of cell wall lipopolysaccharide in Escherichia coli. 3. The isolation and characterization of 3-deoxyoctulosonic acid.

Authors:  M A Ghalambor; E M Levine; E C Heath
Journal:  J Biol Chem       Date:  1966-07-10       Impact factor: 5.157

4.  Transketolase mutants of Escherichia coli.

Authors:  B L Josephson; D G Fraenkel
Journal:  J Bacteriol       Date:  1969-12       Impact factor: 3.490

Review 5.  Current linkage map of Salmonella typhimurium.

Authors:  K E Sanderson
Journal:  Bacteriol Rev       Date:  1970-06

6.  Genetics and cultural properties of mutants of Salmonella typhimurium lacking glucosyl or galactosyl lipopolysaccharide transferases.

Authors:  R G Wilkinson; B A Stocker
Journal:  Nature       Date:  1968-03-09       Impact factor: 49.962

7.  Synthesis and assembly of bacterial membrane components. A lipopolysaccharide-phospholipid-protein complex excreted by living bacteria.

Authors:  L Rothfield; M Pearlman-Kothencz
Journal:  J Mol Biol       Date:  1969-09-28       Impact factor: 5.469

Review 8.  Structure and biosynthesis of the bacterial cell wall.

Authors:  M J Osborn
Journal:  Annu Rev Biochem       Date:  1969       Impact factor: 23.643

9.  The biosynthesis of cell wall lipopolysaccharide in Escherichia coli. IV. Purification and properties of cytidine monophosphate 3-deoxy-d-manno-octulosonate synthetase.

Authors:  M A Ghalambor; E C Heath
Journal:  J Biol Chem       Date:  1966-07-10       Impact factor: 5.157

10.  The biosynthesis of cell wall lipopolysaccharide in Escherichia coli. V. Purification and properties of 3-deoxy-D-manno-octulosonate aldolase.

Authors:  M A Ghalambor; E C Heath
Journal:  J Biol Chem       Date:  1966-07-10       Impact factor: 5.157
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  20 in total

1.  Isolation of Salmonella typhimurium strains that utilize exogenous 3-deoxy-D-manno-octulosonate for synthesis of lipopolysaccharide.

Authors:  R C Goldman; E M Devine
Journal:  J Bacteriol       Date:  1987-11       Impact factor: 3.490

Review 2.  Linkage map of Salmonella typhimurium, edition V.

Authors:  K E Sanderson; P E Hartman
Journal:  Microbiol Rev       Date:  1978-06

Review 3.  Progress in Our Understanding of Wzx Flippase for Translocation of Bacterial Membrane Lipid-Linked Oligosaccharide.

Authors:  Yaoqin Hong; Michael A Liu; Peter R Reeves
Journal:  J Bacteriol       Date:  2017-12-05       Impact factor: 3.490

4.  Purification and characterization of specific 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase from Escherichia coli B.

Authors:  P H Ray; C D Benedict
Journal:  J Bacteriol       Date:  1980-04       Impact factor: 3.490

5.  Isolation and structural analysis of two lipid A precursors from a KDO deficient mutant of Salmonella typhimurium differing in their hexadecanoic acid content.

Authors:  T Hansen-Hagge; V Lehmann; U Seydel; B Lindner; U Zähringer
Journal:  Arch Microbiol       Date:  1985-05       Impact factor: 2.552

6.  Relationship between cell death and altered lipid A synthesis in a temperature-sensitive lethal mutant of Salmonella typhimurium that is conditionally defective in 3-deoxy-D-manno-octulosonate-8-phosphate synthesis.

Authors:  P D Rick; D A Young
Journal:  J Bacteriol       Date:  1982-05       Impact factor: 3.490

7.  Isolation and characterization of a temperature-sensitive lethal mutant of Salmonella typhimurium that is conditionally defective in 3-deoxy-D-manno-octulosonate-8-phosphate synthesis.

Authors:  P D Rick; D A Young
Journal:  J Bacteriol       Date:  1982-05       Impact factor: 3.490

8.  Cloning and characterization of the gene encoding 3-deoxy-D-manno-octulosonate 8-phosphate synthetase from Escherichia coli.

Authors:  M Woisetschläger; G Högenauer
Journal:  J Bacteriol       Date:  1986-10       Impact factor: 3.490

9.  Purification and characterization of cytidine 5'-triphosphate:cytidine 5'-monophosphate-3-deoxy-D-manno-octulosonate cytidylyltransferase.

Authors:  P H Ray; C D Benedict; H Grasmuk
Journal:  J Bacteriol       Date:  1981-03       Impact factor: 3.490

10.  Purification and characterization of 3-deoxy-D-manno-octulosonate 8-phosphate synthetase from Escherichia coli.

Authors:  P H Ray
Journal:  J Bacteriol       Date:  1980-02       Impact factor: 3.490
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