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Literature DB >> 456211

Nonsteroidal antiinflammatory drugs: effect on pyloric sphincter and duodenogastric reflux.

J L Pantoja, C Defilippi, J E Valenzuela, A Csendes.

Abstract

We have investigated the effect of nonsteroidal antiinflammatory drugs on canine pyloric sphincter pressure, mucosal potential difference (PD), and duodenogastric reflux in 5 dogs. Only intragastric aspirin at doses of 30 and 100 mg/kg caused a significant (P less than 0.05) decrease in pyloric sphincter pressure, an increase of duodenogastric reflux, and changed the mucosal PD. Neither intravenous aspirin, intragastric phenylbutazone, or intrarectal indomethacin produced these changes. The mechanism for the aspirin effect may be mediated by local pathways related to changes in mucosal PD. We postulate that increased duodenogastric reflux may be an aggravating factor for the gastric mucosal damage caused by intragastric aspirin.

Entities: Chemical Disease Species

Mesh：

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Year: 1979 PMID： 456211 DOI： 10.1007/bf01308433

Source DB: PubMed Journal: Dig Dis Sci ISSN： 0163-2116 Impact factor: 3.199

14 in total

1. PATHOGENESIS OF GASTRIC ULCERATION.

Authors: D J DUPLESSIS
Journal: Lancet Date: 1965-05-08 Impact factor: 79.321

Review 2. Progress report. Aspirin in chronic gastric ulcer: an Australian experience.

Authors: J M Duggan
Journal: Gut Date: 1976-05 Impact factor: 23.059

3. Gastric mucosal lesions produced by intravenous infusion of aspirin in cats.

Authors: R Bugat; M R Thompson; D Aures; M I Grossman
Journal: Gastroenterology Date: 1976-11 Impact factor: 22.682

4. Prevention of aspirin-induced gastric ulceration by bile duct or pylorus ligation in the rat.

Authors: B Djahanguiri; F S Abtahi; M Hemmati
Journal: Gastroenterology Date: 1973-10 Impact factor: 22.682

5. Pyloric-sphincter dysfunction in patients with gastric ulcer.

Authors: R S Fisher; S Cohen
Journal: N Engl J Med Date: 1973-02-08 Impact factor: 91.245

6. Physiological characteristics of the human pyloric sphincter.

Authors: R Fisher; S Cohen
Journal: Gastroenterology Date: 1973-01 Impact factor: 22.682

7. Pyloric-sphincter studies in peptic-ulcer patients: pylorus in peptic ulcer.

Authors: J E Valenzuela; C Defilippi
Journal: Am J Dig Dis Date: 1976-03

8. Experimental esophagitis in cats impairs lower esophageal sphincter pressure.

Authors: G L Eastwood; D O Castell; R H Higgs
Journal: Gastroenterology Date: 1975-07 Impact factor: 22.682

9. Response of the human cardia sphincter to circulating prostaglandins F2ALPHA and E2 and to antiinflammatory drugs.

Authors: J B Dilawari; A Newman; J Poleo; J J Misiewicz
Journal: Gut Date: 1975-02 Impact factor: 23.059

10. Phenylbutazone (butazolidin); effect on basal gastric secretion and the production of gastroduodenal ulcerations in dogs.

Authors: J B KIRSNER; H FORD
Journal: Gastroenterology Date: 1955-07 Impact factor: 22.682

7 in total

7. Double-blind, placebo-controlled study on effects of diclofenac sodium and indomethacin on postprandial gastric motility in man.

Authors: G Bassotti; G Bucaneve; P Furno; A Morelli; A Del Favero
Journal: Dig Dis Sci Date: 1998-06 Impact factor: 3.199

7 in total

Nonsteroidal antiinflammatory drugs: effect on pyloric sphincter and duodenogastric reflux.

1. PATHOGENESIS OF GASTRIC ULCERATION.

Review 2. Progress report. Aspirin in chronic gastric ulcer: an Australian experience.

3. Gastric mucosal lesions produced by intravenous infusion of aspirin in cats.

4. Prevention of aspirin-induced gastric ulceration by bile duct or pylorus ligation in the rat.

5. Pyloric-sphincter dysfunction in patients with gastric ulcer.

6. Physiological characteristics of the human pyloric sphincter.

7. Pyloric-sphincter studies in peptic-ulcer patients: pylorus in peptic ulcer.

8. Experimental esophagitis in cats impairs lower esophageal sphincter pressure.

9. Response of the human cardia sphincter to circulating prostaglandins F2ALPHA and E2 and to antiinflammatory drugs.

10. Phenylbutazone (butazolidin); effect on basal gastric secretion and the production of gastroduodenal ulcerations in dogs.

Review 1. Nonsteroidal anti-inflammatory agents: species differences in pharmacodynamics.

2. Effects of parenteral diclofenac sodium on upper gastrointestinal motility after food in man.

3. Continuous recording of pyloric sphincter pressure in dogs. Relationship to migratory motor complex.

4. Effects of aspirin and prostaglandin E2 on interdigestive motility complex and duodenogastric reflux in man.

5. Relationship between antropyloric and intestinal motility and duodenogastric reflux in fasting dogs.

6. Cisapride stimulates antral motility and decreases biliary reflux in patients with severe dyspepsia.

7. Double-blind, placebo-controlled study on effects of diclofenac sodium and indomethacin on postprandial gastric motility in man.