Literature DB >> 4559828

Methionine adenosyltransferase and ethionine resistance in Saccharomyces cerevisiae.

J E Mertz, K D Spence.   

Abstract

The methionine adenosyltransferase is repressed in Saccharomyces cerevisiae during growth in the presence of excess methionine. The relationship of this repression to the level of intracellular S-adenosylmethionine is discussed. In conjunction with these studies, an ethionine-resistant mutant has been investigated which has a low level of methionine adenosyltransferase under all conditions tested. The mechanism of ethionine resistance in the latter strain apparently depends on its inability to form large quantities of intracellular S-adenosylethionine. With respect to the methionine adenosyltransferase, there is no apparent interaction between ethionine-resistant and ethionine-sensitive alleles when both are present in the heterozygous diploid.

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Year:  1972        PMID： 4559828      PMCID： PMC251352          DOI： 10.1128/jb.111.3.778-783.1972

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  27 in total

1.  Methods for the analysis and preparation of adenosylmethionine and adenosylhomocysteine.

Authors:  S K Shapiro; D J Ehninger
Journal:  Anal Biochem       Date:  1966-05       Impact factor: 3.365

2.  Spectrophotometric determination of microgram quantities of protein without nucleic acid interference.

Authors:  W E Groves; F C Davis; B H Sells
Journal:  Anal Biochem       Date:  1968-02       Impact factor: 3.365

3.  Methionine biosynthesis from the 4-carbon skeleton of ethionine in Saccharomyces cerevisiae.

Authors:  H Cherest; G Talbot; H Robichon-Szulmajster
Journal:  Biochem Biophys Res Commun       Date:  1968-08-21       Impact factor: 3.575

4.  The production of S-adenosyl-L-methionine and S-adenosyl-L-ethionine by yeast.

Authors:  F Schlenk; C R Zydek; D J Ehninger; J L Dainko
Journal:  Enzymologia       Date:  1965-11-06

5.  Studies on the basis of ethionine-resistance in Neurospora.

Authors:  M S Kappy; R L Metzenberg
Journal:  Biochim Biophys Acta       Date:  1965-10-18

6.  Comparative studies on methionine, selenomethionine, and their ethyl analogues as substrates for methionine adenosyltransferase from rat liver.

Authors:  F Pan; H Tarver
Journal:  Arch Biochem Biophys       Date:  1967-03       Impact factor: 4.013

7.  Incorporation and distribution of ethionine-sulfur in the protein of ethionine-sensitive and ethionine-resistant yeasts.

Authors:  G A Maw
Journal:  Arch Biochem Biophys       Date:  1966-08       Impact factor: 4.013

8.  [Properties and genetic control of the system for accumulation of amino acids in Saccharomyces cerevisiae].

Authors:  Y Surdin; W Sly; J Sire; A M Bordes; H Robichon-Szulmajster
Journal:  Biochim Biophys Acta       Date:  1965-10-18

9.  Genetic and regulatory aspects of methionine biosynthesis in Saccharomyces cerevisiae.

Authors:  H Cherest; F Eichler; H Robichon-Szulmajster
Journal:  J Bacteriol       Date:  1969-01       Impact factor: 3.490

10.  Dominant mutation for ethionine resistance in Saccharomyces cerevisae.

Authors:  K D Spence; L W Parks; S K Shapiro
Journal:  J Bacteriol       Date:  1967-11       Impact factor: 3.490
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  12 in total

1.  A dominant negative effect of eth-1r, a mutant allele of the Neurospora crassa S-adenosylmethionine synthetase-encoding gene conferring resistance to the methionine toxic analogue ethionine.

Authors:  J L Barra; M R Mautino; A L Rosa
Journal:  Genetics       Date:  1996-12       Impact factor: 4.562

2.  Deficiency in methionine adenosyltransferase resulting in limited repressibility of methionine biosynthetic enzymes in Aspergillus nidulans.

Authors:  N J Pieniazek; I M Kowalska; P P Stepień
Journal:  Mol Gen Genet       Date:  1973-11-22

3.  Specificity and genetics of S-adenosylmethionine transport in Saccharomyces cerevisiae.

Authors:  T F Petrotta-Simpson; J E Talmadge; K D Spence
Journal:  J Bacteriol       Date:  1975-08       Impact factor: 3.490

Review 4.  Molecular aspects of the in vivo and in vitro effects of ethionine, an analog of methionine.

Authors:  J H Alix
Journal:  Microbiol Rev       Date:  1982-09

5.  Induction and repression in the S-adenosylmethionine and methionine biosynthetic systems of Saccharomyces cerevisiae.

Authors:  A J Ferro; K D Spence
Journal:  J Bacteriol       Date:  1973-11       Impact factor: 3.490

6.  S-adenosyl methionine requiring mutants in Saccharomyces cerevisiae: evidences for the existence of two methionine adenosyl transferases.

Authors:  H Cherest; Y Surdin-Kerjan
Journal:  Mol Gen Genet       Date:  1978-07-11

7.  Effects of regulatory mutations upon methionine biosynthesis in Saccharomyces cerevisiae: loci eth2-eth3-eth10.

Authors:  H Cherest; Y Surdin-Kerjan; J Antoniewski; H de Robichon-Szulmajster
Journal:  J Bacteriol       Date:  1973-09       Impact factor: 3.490

8.  S-adenosyl methionine-mediated repression of methionine biosynthetic enzymes in Saccharomyces cerevisiae.

Authors:  H Cherest; Y Surdin-Kerjan; J Antoniewski; H Robichon-Szulmajster
Journal:  J Bacteriol       Date:  1973-06       Impact factor: 3.490

9.  Genetic mapping and physiological consequences of metE mutations of Bacillus subtilis.

Authors:  H Wabiko; K Ochi; D M Nguyen; E R Allen; E Freese
Journal:  J Bacteriol       Date:  1988-06       Impact factor: 3.490

10.  Stimulation of yeast ascospore germination and outgrowth by S-adenosylmethionine.

Authors:  J V Brawley; A J Ferro
Journal:  J Bacteriol       Date:  1980-05       Impact factor: 3.490
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