Literature DB >> 4559733

Effect of cyclopentaneglycine on metabolism in Salmonella typhimurium.

J P O'Neill, M Freundlich.   

Abstract

Cyclopentaneglycine (CPG) inhibited the growth of wild-type Salmonella typhimurium. The inhibition was overcome by isoleucine or any isoleucine precursor formed after threonine. CPG appeared to mimic isoleucine as a strong inhibitor of the activity of l-threonine deaminase. The analogue was a poor inhibitor of isoleucyl-transfer ribonucleic acid synthetase. CPG did not appear to be incorporated into protein nor did it replace isoleucine in repression. Cells that had recovered from growth inhibition by CPG had derepressed levels of the isoleucine-valine biosynthetic enzymes.

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Year:  1972        PMID： 4559733      PMCID： PMC251312          DOI： 10.1128/jb.111.2.510-515.1972

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  21 in total

1.  EFFECT OF ALPHA-METHYLHISTIDINE ON THE CONTROL OF HISTIDINE SYNTHESIS.

Authors:  S SCHLESINGER; B MAGASANIK
Journal:  J Mol Biol       Date:  1964-09       Impact factor: 5.469

2.  Control of isoleucine, valine, and leucine biosynthesis. I. Multivalent repression.

Authors:  M FREUNDLICH; R O BURNS; H E UMBARGER
Journal:  Proc Natl Acad Sci U S A       Date:  1962-10-15       Impact factor: 11.205

3.  Threonine deamination in Escherichia coli. I. D- and L-threonine deaminase activities of cell-free extracts.

Authors:  H E UMBARGER; B BROWN
Journal:  J Bacteriol       Date:  1956-04       Impact factor: 3.490

4.  Threonine deamination in Escherichia coli. II. Evidence for two L-threonine deaminases.

Authors:  H E UMBARGER; B BROWN
Journal:  J Bacteriol       Date:  1957-01       Impact factor: 3.490

5.  Evidence for a negative-feedback mechanism in the biosynthesis of isoleucine.

Authors:  H E UMBARGER
Journal:  Science       Date:  1956-05-11       Impact factor: 47.728

6.  Mutants of Escherichia coli requiring methionine or vitamin B12.

Authors:  B D DAVIS; E S MINGIOLI
Journal:  J Bacteriol       Date:  1950-07       Impact factor: 3.490

7.  Histidine regulatory mutants in Salmonella typhimurium. I. Isolation and general properties.

Authors:  J R Roth; D N Antón; P E Hartman
Journal:  J Mol Biol       Date:  1966-12-28       Impact factor: 5.469

8.  Regulation of branched-chain amino acid biosynthesis in Salmonella typhimurium: isolation of regulatory mutants.

Authors:  J M Calvo; M Freundlich; H E Umbarger
Journal:  J Bacteriol       Date:  1969-03       Impact factor: 3.490

9.  Isoleucine and valine metabolism of Escherichia coli. XV. Biochemical properties of mutants resistant to thiaisoleucine.

Authors:  A Szentirmai; M Szentirmai; H E Umbarger
Journal:  J Bacteriol       Date:  1968-05       Impact factor: 3.490

10.  Histidine regulatory mutants in Salmonella typhimurium 3. A class of regulatory mutants deficient in tRNA for histidine.

Authors:  D F Silbert; G R Fink; B N Ames
Journal:  J Mol Biol       Date:  1966-12-28       Impact factor: 5.469
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  6 in total

1.  YjgF is required for isoleucine biosynthesis when Salmonella enterica is grown on pyruvate medium.

Authors:  Melissa R Christopherson; G E Schmitz; Diana M Downs
Journal:  J Bacteriol       Date:  2008-02-22       Impact factor: 3.490

Review 2.  Linkage map of Salmonella typhimurium, edition V.

Authors:  K E Sanderson; P E Hartman
Journal:  Microbiol Rev       Date:  1978-06

3.  Temperature-sensitive growth inhibition by valine in Salmonella typhimurium: alteration of one form of acetohydroxy acid synthetase.

Authors:  J P O'Neill; M Freundlich
Journal:  J Bacteriol       Date:  1973-10       Impact factor: 3.490

4.  Mutations in genes cpxA and cpxB of Escherichia coli K-12 cause a defect in acetohydroxyacid synthase I function in vivo.

Authors:  A Sutton; T Newman; J McEwen; P M Silverman; M Freundlich
Journal:  J Bacteriol       Date:  1982-08       Impact factor: 3.490

5.  Derepressed levels of the isoleucine-valine and leucine enzymes in his T 1504, a strain of Salmonella typhimurium with altered leucine transfer ribonucleic acid.

Authors:  A A Rizzino; R S Bresalier; M Freundlich
Journal:  J Bacteriol       Date:  1974-02       Impact factor: 3.490

6.  Pleiotropy of hisT mutants blocked in pseudouridine synthesis in tRNA: leucine and isoleucine-valine operons.

Authors:  R Cortese; R Landsberg; R A Haar; H E Umbarger; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1974-05       Impact factor: 11.205
  6 in total

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