| Literature DB >> 4551980 |
A W Coleman, J R Coleman, J D Griffin, J K Weltman, K M Chapman.
Abstract
Relatively low concentrations of methylxanthines increase spontaneous twitching in cultured muscle fibers; they also cause a second activity, escalation, which is the initiation and undiminished propagation of visible waves. The effect on twitching is abolished by depolarizing concentrations of K(+) or by tetrodotoxin; the effect on escalation is not. Escalation is prevented by removal of external Ca(++) or by the addition of tetracaine.Entities:
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Year: 1972 PMID： 4551980 PMCID： PMC426518 DOI： 10.1073/pnas.69.3.613
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205