Literature DB >> 4550859

Linear relationships between lipophilic character and biological activity of drugs.

C Hansch, W J Dunn.   

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Year:  1972        PMID: 4550859     DOI: 10.1002/jps.2600610102

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN: 0022-3549            Impact factor:   3.534


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  41 in total

1.  Localization and quantification of hydrophobicity: the molecular free energy density (MolFESD) concept and its application to sweetness recognition.

Authors:  R Jäger; F Schmidt; B Schilling; J Brickmann
Journal:  J Comput Aided Mol Des       Date:  2000-10       Impact factor: 3.686

2.  Antitumor activity of kielmeyera coriacea leaf constituents in experimental melanoma, tested in vitro and in vivo in syngeneic mice.

Authors:  Carlos Rogério Figueiredo; Alisson Leonardo Matsuo; Mariana Hiromi Massaoka; Natalia Girola; Ricardo Alexandre Azevedo; Aline Nogueira Rabaça; Camyla Fernandes Farias; Felipe Valença Pereira; Natalia Silva Matias; Luciana Pereira Silva; Elaine Guadelupe Rodrigues; João Henrique Guilardi Lago; Luiz Rodolpho Travassos; Regildo Márcio Gonçalves Silva
Journal:  Adv Pharm Bull       Date:  2014-08-25

3.  Activity of phosphatidylinositol transfer protein is sensitive to ethanol and membrane curvature.

Authors:  H Komatsu; B Bouma; K W Wirtz; T F Taraschi; N Janes
Journal:  Biochem J       Date:  2000-06-15       Impact factor: 3.857

4.  Liposomes as a model for the biological membrane: studies on daunorubicin bilayer interaction.

Authors:  Carla Matos; Carla Moutinho; Paulo Lobão
Journal:  J Membr Biol       Date:  2012-01-01       Impact factor: 1.843

5.  High-throughput microplate assay for the determination of drug partition coefficients.

Authors:  Luís M Magalhães; Cláudia Nunes; Marlene Lúcio; Marcela A Segundo; Salette Reis; José L F C Lima
Journal:  Nat Protoc       Date:  2010-10-21       Impact factor: 13.491

6.  Breaking the Meyer-Overton rule: predicted effects of varying stiffness and interfacial activity on the intrinsic potency of anesthetics.

Authors:  R S Cantor
Journal:  Biophys J       Date:  2001-05       Impact factor: 4.033

Review 7.  Modeling kinetics of subcellular disposition of chemicals.

Authors:  Stefan Balaz
Journal:  Chem Rev       Date:  2009-05       Impact factor: 60.622

8.  Liposomes as carriers of poorly water-soluble substrates: linear modelling of membrane systems with catalytic or binding sites of different facedness. Significance of experimental membrane partition coefficients and of kinetic and equilibrium parameters.

Authors:  K P Heirwegh; J A Meuwissen; M Vermeir; H De Smedt
Journal:  Biochem J       Date:  1988-08-15       Impact factor: 3.857

9.  Relationship of alcohol-induced changes in Mg(2+)-ATPase activity of rabbit intestinal brush border membrane with changes in fluidity of its lipid bilayer.

Authors:  S Kitagawa; Y Sugaya; M Nishizawa; H Hirata
Journal:  J Membr Biol       Date:  1995-07       Impact factor: 1.843

Review 10.  Back to the future: can physical models of passive membrane permeability help reduce drug candidate attrition and move us beyond QSPR?

Authors:  Robert V Swift; Rommie E Amaro
Journal:  Chem Biol Drug Des       Date:  2013-01       Impact factor: 2.817

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