Literature DB >> 5450697

Tumorigenesis in mouse skin: inhibition by synthetic inhibitors of proteases.

W Troll, A Klassen, A Janoff.   

Abstract

Three synthetic inhibitors of proteases (tosyl lysine chloromethyl ketone, tosyl phenylalanine chloromethyl ketone, and tosyl arginine methyl ester) inhibit the tumorigenesis initiated in mouse skin by 7,12-dimethylbenz(a)anthracene and promoted by croton oil or its active principle, phorbol ester. These protease inhibitors, when applied directly to mouse skin, inhibit some of the irritant effects of the tumor promoter and are not toxic.

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Year:  1970        PMID： 5450697     DOI： 10.1126/science.169.3951.1211

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  37 in total

1.  A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development.

Authors:  Xiuning Le; Emily K Pugach; Simone Hettmer; Narie Y Storer; Jianing Liu; Airon A Wills; Antony DiBiase; Eleanor Y Chen; Myron S Ignatius; Kenneth D Poss; Amy J Wagers; David M Langenau; Leonard I Zon
Journal:  Development       Date:  2013-04-24       Impact factor: 6.868

2.  Human skin proteases. Fractionation of psoriasis scale proteases and separation of a plasminogen activator and a histone hydrolysing protease.

Authors:  J E Fräki; V K Hopsu-Havu
Journal:  Arch Dermatol Res       Date:  1976-08-27       Impact factor: 3.017

Review 3.  Lysosomes in cancer cells.

Authors:  A C Allison
Journal:  J Clin Pathol Suppl (R Coll Pathol)       Date:  1974

Review 4.  Leukocytic proteases and the immunologic release of lysosomal enzymes.

Authors:  G Weissmann; R B Zurier; S Hoffstein
Journal:  Am J Pathol       Date:  1972-09       Impact factor: 4.307

5.  Selective inhibition of growth of transformed cells by protease inhibitors.

Authors:  H P Schnebli; M M Burger
Journal:  Proc Natl Acad Sci U S A       Date:  1972-12       Impact factor: 11.205

6.  Stimulation of cell division by croton oil in blue-green bacteria.

Authors:  L O Ingram; W D Fisher
Journal:  J Bacteriol       Date:  1973-05       Impact factor: 3.490

7.  Regulation of normal differentiation in mouse and human myeloid leukemic cells by phorbol esters and the mechanism of tumor promotion.

Authors:  J Lotem; L Sachs
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

8.  Plasminogen activator induction and platelet aggregation by phorbol and some of its derivatives: correlation with skin irritancy and tumor-promoting activity.

Authors:  P J Brynes; R Schmidt; E Hecker
Journal:  J Cancer Res Clin Oncol       Date:  1980       Impact factor: 4.553

9.  Inhibiting the onset of hormone-induced desentiziation of viable thymocytes by N alpha-tosyl-L-lysine chloromethyl ketone.

Authors:  Y Zick; R Cesla; S Shaltiel
Journal:  Proc Natl Acad Sci U S A       Date:  1980-10       Impact factor: 11.205

10.  TPCK inhibits AGC kinases by direct activation loop adduction at phenylalanine-directed cysteine residues.

Authors:  Rana Anjum; Eunice Pae; John Blenis; Bryan A Ballif
Journal:  FEBS Lett       Date:  2012-08-10       Impact factor: 4.124
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