Literature DB >> 4544248

Autoradiographic studies on the proliferation of antibody-producing cells in vitro.

T Hünig, A Schimpl, E Wecker.   

Abstract

A rapid and reliable autoradiographic technique for plaque-forming cells (PFCs) using (14)C rather than tritiated thymidine is described. Its application to PFCs developing in vitro shows that (a) practically all PFCs derive from precursors dividing steadily during the culture period, (b) PFC precursors divide in the absence of T-cell helper function, and (c) at least some PFCs may continue to divide.

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Year:  1974        PMID： 4544248      PMCID： PMC2139546          DOI： 10.1084/jem.139.3.754

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  10 in total

1.  Plaque formation in agar by single antibody-producing cells.

Authors:  N K JERNE; A A NORDIN
Journal:  Science       Date:  1963-04-26       Impact factor: 47.728

2.  Direct conversion of precursors of PFCs into active PFCs in vitro, without prior cell division.

Authors:  D Sulitzeanu; J Marbrook; J S Haskill
Journal:  Immunology       Date:  1973-04       Impact factor: 7.397

3.  Inhibition of in vitro immune response by treatment of spleen cell suspensions with anti-theta serum.

Authors:  A Schimpl; E Wecker
Journal:  Nature       Date:  1970-06-27       Impact factor: 49.962

4.  The early antibody-forming response to Salmonella antigens. A study of morphology and kinetics in vivo and in vitro.

Authors:  P J Russell; E Diener
Journal:  Immunology       Date:  1970-10       Impact factor: 7.397

5.  Autoradiographic studies on the immune response. II. DNA synthesis amongst single antibody-producing cells.

Authors:  O MAKELA; G J NOSSAL
Journal:  J Exp Med       Date:  1962-01-01       Impact factor: 14.307

6.  Studies on the source and action of the T-cell replacing factor (TRF).

Authors:  A Schimpl; E Wecker
Journal:  Adv Exp Med Biol       Date:  1973       Impact factor: 2.622

7.  Immunization of dissociated spleen cell cultures from normal mice.

Authors:  R I Mishell; R W Dutton
Journal:  J Exp Med       Date:  1967-09-01       Impact factor: 14.307

8.  Stimulation of IgG antibody response in vitro by T cell-replacing factor.

Authors:  A Schimpl; E Wecker
Journal:  J Exp Med       Date:  1973-02-01       Impact factor: 14.307

9.  Autoradiographic studies on the immune response.I. The kinetics of plasma cell proliferation.

Authors:  G J NOSSAL; O MAKELA
Journal:  J Exp Med       Date:  1962-01-01       Impact factor: 14.307

10.  Cell populations and cell proliferation in the in vitro response of normal mouse spleen to heterologous erythrocytes. Analysis by the hot pulse technique.

Authors:  R W Dutton; R I Mishell
Journal:  J Exp Med       Date:  1967-09-01       Impact factor: 14.307
  10 in total
  13 in total

1.  Optimal strategies in immunology. I. B-cell differentiation and proliferation.

Authors:  A S Perelson; M Mirmirani; G F Oster
Journal:  J Math Biol       Date:  1976-11-25       Impact factor: 2.259

2.  The requirement for the expression of previously unexpressed genes in the generation of T and B antigen-binding cells and the changes in sIg isotype following in vitro immunization.

Authors:  J E Merrill; R F Ashman
Journal:  Immunology       Date:  1979-11       Impact factor: 7.397

3.  IgG anti-hapten antibody secretion in vitro commences after extensive precursor proliferation.

Authors:  J T Kemshead; J R North; B A Askonas
Journal:  Immunology       Date:  1977-10       Impact factor: 7.397

Review 4.  Multiple thymus-derived helper cell activities involved in antibody responses.

Authors:  R O Endres; P Marrack
Journal:  Surv Immunol Res       Date:  1982

5.  Cyclic development of immunological memory to bacterial lipopolysaccharide.

Authors:  P J Baker; J R Hiernaux; P W Stashak; J A Rudbach
Journal:  Infect Immun       Date:  1985-04       Impact factor: 3.441

6.  Accelerated cytodifferentiation of antibody-secreting cells in guinea-pig lymph nodes stimulated by sheep erythrocytes and lymphokines.

Authors:  R H Kelly; V S Harvey; T E Sadler; D C Dumonde
Journal:  Clin Exp Immunol       Date:  1975-07       Impact factor: 4.330

7.  B-cell growth factor: distinction from T-cell growth factor and B-cell maturation factor.

Authors:  T Leanderson; E Lundgren; E Ruuth; H Borg; H Persson; A Coutinho
Journal:  Proc Natl Acad Sci U S A       Date:  1982-12       Impact factor: 11.205

8.  The immunodepressive effect of Friend virus. IV. Effects on spleen B lymphocytes.

Authors:  B N Dracott; N Wedderburn; M J Doenhoff
Journal:  Immunology       Date:  1978-04       Impact factor: 7.397

9.  Modulation of cellular immune responses in mice with disseminated histoplasmosis by recombinant interleukin-2.

Authors:  G S Deepe; C L Taylor; J E Harris; W E Bullock
Journal:  Infect Immun       Date:  1986-07       Impact factor: 3.441

10.  Immunological responses of mice to native protoplasmic polysaccharide and lipopolysaccharide: functional separation of the two signals required to stimulate a secondary antibody response.

Authors:  K B Von Eschen; J A Rudbach
Journal:  J Exp Med       Date:  1974-12-01       Impact factor: 14.307
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