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Literature DB >> 4537952

Genetic variants of von Willebrand's disease.

Abstract

A specific antiserum against an antihaemophilic factor (AHF)-related plasma protein was raised in rabbits. A quantitative immunochemical method was used to determine the amount of this protein present in the plasma of 33 patients with haemophilia A and 70 patients with von Willebrand's disease. The protein probably consisted of AHF residing in or complexed with the von Willebrand factor. The patients with von Willebrand's disease were shown to fall into two separate genetic groups, one with decreased and one with normal amounts of the AHF-related protein. The patients with haemophilia A had normal amounts of the protein in their plasma.

Entities: Disease Species

Mesh：

Substances：
Immune Sera
Factor VIII

Year: 1972 PMID： 4537952 PMCID： PMC1785514 DOI： 10.1136/bmj.3.5822.317

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

19 in total

1. Pool's cryoprecipitate and exhausted plasma in the treatment of von Willebrand's disease and factor-XI deficiency.

Authors: E Bennett; K Dormandy
Journal: Lancet Date: 1966-10-01 Impact factor: 79.321

2. Studies on the platelet adhesiveness in von Willebrand's disease.

Authors: S Cronberg; I M Nilsson; J Silwer
Journal: Acta Med Scand Date: 1966-07

3. Our experience in Sweden with prophylaxis on haemophilia.

Authors: I M Nilsson; M Blombäck; A Ahlberg
Journal: Bibl Haematol Date: 1970

4. Purification of human antihemophilic factor (factor VIII) by gel chromatography.

Authors: J A van Mourik; I A Mochtar
Journal: Biochim Biophys Acta Date: 1970-12-22

5. Immunological differentiation of three types of haemophilia and identification of some female carriers.

Authors: E Bennett; E R Huehns
Journal: Lancet Date: 1970-11-07 Impact factor: 79.321

6. Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies.

Authors: C B Laurell
Journal: Anal Biochem Date: 1966-04 Impact factor: 3.365

7. Factor 8 detection by hemagglutination inhibition: hemophilia A and von Willebrand's disease.

Authors: D P Stites; E J Hershgold; J D Perlman; H H Fudenberg
Journal: Science Date: 1971-01-15 Impact factor: 47.728

8. Studies on the purification of antihemophilic factor (factor VIII). II. Separation of partially purified antihemophilic factor by gel filtration of plasma.

Authors: O D Ratnoff; L Kass; P D Lang
Journal: J Clin Invest Date: 1969-05 Impact factor: 14.808

9. Immunologic differentiation of classic hemophilia (factor 8 deficiency) and von Willebrand's dissase, with observations on combined deficiencies of antihemophilic factor and proaccelerin (factor V) and on an acquired circulating anticoagulant against antihemophilic factor.

Authors: T S Zimmerman; O D Ratnoff; A E Powell
Journal: J Clin Invest Date: 1971-01 Impact factor: 14.808

10. Congenital bleeding disorders with long bleeding time and normal platelet count. II. Von Willebrand's disease (report of thirty-seven patients).

Authors: M J Larrieu; J P Caen; D O Meyer; H Vainer; Y Sultan; J Bernard
Journal: Am J Med Date: 1968-09 Impact factor: 4.965

10 in total

10. Quantitative assay of a plasma factor deficient in von Willebrand's disease that is necessary for platelet aggregation. Relationship to factor VIII procoagulant activity and antigen content.

Authors: H J Weiss; L W Hoyer; F R Rickles; A Varma; J Rogers
Journal: J Clin Invest Date: 1973-11 Impact factor: 14.808

10 in total

Genetic variants of von Willebrand's disease.

1. Pool's cryoprecipitate and exhausted plasma in the treatment of von Willebrand's disease and factor-XI deficiency.

2. Studies on the platelet adhesiveness in von Willebrand's disease.

3. Our experience in Sweden with prophylaxis on haemophilia.

4. Purification of human antihemophilic factor (factor VIII) by gel chromatography.

5. Immunological differentiation of three types of haemophilia and identification of some female carriers.

6. Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies.

7. Factor 8 detection by hemagglutination inhibition: hemophilia A and von Willebrand's disease.

8. Studies on the purification of antihemophilic factor (factor VIII). II. Separation of partially purified antihemophilic factor by gel filtration of plasma.

9. Immunologic differentiation of classic hemophilia (factor 8 deficiency) and von Willebrand's dissase, with observations on combined deficiencies of antihemophilic factor and proaccelerin (factor V) and on an acquired circulating anticoagulant against antihemophilic factor.

10. Congenital bleeding disorders with long bleeding time and normal platelet count. II. Von Willebrand's disease (report of thirty-seven patients).

1. Von Willebrand's disease.

2. von Willebrand's disease in identical twins.

3. Surgery in von Willebrand's disease.

4. Factor VIII-related antigen in tissues detected by the indirect immunofluorescence technique.

5. Studies on the altered electrophoretic type of the factor VIII related antigen.

6. [Von Willebrand-Jürgens syndrome with a variant of factor VIII-associated antigen].

7. Effect of dextran on factor VIII (antihemophilic factor) and platelet function.

8. Mutational Constraints on Local Unfolding Inhibit the Rheological Adaptation of von Willebrand Factor.

9. The defect in hemophilic and von Willebrand's disease plasmas studied by a recombination technique.

10. Quantitative assay of a plasma factor deficient in von Willebrand's disease that is necessary for platelet aggregation. Relationship to factor VIII procoagulant activity and antigen content.