Literature DB >> 4526303

The somatic cell genetics of human interferon: assignment of human interferon loci to chromosomes 2 and 5.

Y H Tan, R P Creagan, F H Ruddle.   

Abstract

A total of 40 mouse-human cell hybrids were induced with poly(I).poly(C) and with Newcastle disease virus. Ten hybrid clones produced low levels of human interferon in response to both the virus and poly(I).poly(C). Concurrent enzymic and chromosomal analysis of the hybrid clones indicated a concordant segregation of these levels of human interferon with chromosomes 2 and 5. The presence of both chromosomes 2 and 5 was necessary for interferon production; neither was sufficient alone. Based on this finding, we postulate that there are at least two asyntenic gene loci for the expression of interferon in human cells.

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Year:  1974        PMID： 4526303      PMCID： PMC388429          DOI： 10.1073/pnas.71.6.2251

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  19 in total

1.  SELECTION OF HYBRIDS FROM MATINGS OF FIBROBLASTS IN VITRO AND THEIR PRESUMED RECOMBINANTS.

Authors:  J W LITTLEFIELD
Journal:  Science       Date:  1964-08-14       Impact factor: 47.728

2.  Post-transcriptional control of interferon synthesis.

Authors:  J Vilcek; M H Ng
Journal:  J Virol       Date:  1971-05       Impact factor: 5.103

3.  Evolutionary conservatism in arrangement of genetic material. A comparative analysis of chromosome banding between the rhesus macaque (2n equals 42, 84 arms) and the African green monkey (2n equals 60, 120 arms).

Authors:  A D Stock; T C Hsu
Journal:  Chromosoma       Date:  1973-08-10       Impact factor: 4.316

4.  Human lymphoblastoid lines from lymph node and spleen.

Authors:  J A Levy; M Virolainen; V Defendi
Journal:  Cancer       Date:  1968-09       Impact factor: 6.860

5.  Use of monkey-mouse hybrid cells for the study of the cellular regualtion of interferon production and action.

Authors:  R Cassingena; C Chany; M Vignal; H Suarez; S Estrade; P Lazar
Journal:  Proc Natl Acad Sci U S A       Date:  1971-03       Impact factor: 11.205

6.  The 24 fluorescence patterns of the human metaphase chromosomes - distinguishing characters and variability.

Authors:  T Caspersson; G Lomakka; L Zech
Journal:  Hereditas       Date:  1972       Impact factor: 3.271

7.  Inhibition of interferon action by actinomycin.

Authors:  J Taylor
Journal:  Biochem Biophys Res Commun       Date:  1964       Impact factor: 3.575

8.  An enzyme-based theory of obligate anaerobiosis: the physiological function of superoxide dismutase.

Authors:  J M McCord; B B Keele; I Fridovich
Journal:  Proc Natl Acad Sci U S A       Date:  1971-05       Impact factor: 11.205

9.  Genetic analysis with man-mouse somatic cell hybrids. Linkage between human lactate dehydrogenase A and B and peptidase B.

Authors:  F H Ruddle; V M Chapman; T R Chen; R J Klebe
Journal:  Nature       Date:  1970-07-18       Impact factor: 49.962

10.  Regulation of cellular interferon production: enhancement by antimetabolites.

Authors:  Y H Tan; J A Armstrong; Y H Ke; M Ho
Journal:  Proc Natl Acad Sci U S A       Date:  1970-09       Impact factor: 11.205
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  20 in total

1.  T-antigen expression in human skin fibroblasts is not regulated by an endogenous interferon response to SV40 infection.

Authors:  A S Lubiniecki; W A Blattner; V Cruttenden; M Gunnell; G C Tarr; J F Fraumeni
Journal:  Arch Virol       Date:  1978       Impact factor: 2.574

2.  Presence of human chromosome 21 alone is sufficient for hybrid cell sensitivity to human interferon.

Authors:  D L Slate; L Shulman; J B Lawrence; M Revel; F H Ruddle
Journal:  J Virol       Date:  1978-01       Impact factor: 5.103

3.  Human interferon: mass production in a newly established cell line, MG-63.

Authors:  A Billiau; V G Edy; H Heremans; J Van Damme; J Desmyter; J A Georgiades; P De Somer
Journal:  Antimicrob Agents Chemother       Date:  1977-07       Impact factor: 5.191

4.  Relationship between interferon production and interferon messenger RNA synthesis in human fibroblasts.

Authors:  N B Raj; P M Pitha
Journal:  Proc Natl Acad Sci U S A       Date:  1977-04       Impact factor: 11.205

5.  Enucleation and reconstruction of interferon-producing cells.

Authors:  D C Burke; G Veomett
Journal:  Proc Natl Acad Sci U S A       Date:  1977-08       Impact factor: 11.205

Review 6.  Interferons: anti-neoplastic drugs?

Authors:  H Strander
Journal:  Blut       Date:  1977-09-18

Review 7.  Differences between human alpha (leukocyte) and beta (fibroblast) interferons.

Authors:  T G Hayes
Journal:  Arch Virol       Date:  1981       Impact factor: 2.574

8.  Aging in vitro and large-scale interferon production by 15 new strains of human diploid fibroblasts.

Authors:  J S Horoszewicz; S S Leong; M Ito; L Di Berardino; W A Carter
Journal:  Infect Immun       Date:  1978-02       Impact factor: 3.441

9.  Leukocyte and fibroblast interferon genes are located on human chromosome 9.

Authors:  D Owerbach; W J Rutter; T B Shows; P Gray; D V Goeddel; R M Lawn
Journal:  Proc Natl Acad Sci U S A       Date:  1981-05       Impact factor: 11.205

10.  Genetics of the connective tissue proteins: assignment of the gene for human type I procollagen to chromosome 17 by analysis of cell hybrids and microcell hybrids.

Authors:  C V Sundar Raj; R L Church; L A Klobutcher; F H Ruddle
Journal:  Proc Natl Acad Sci U S A       Date:  1977-10       Impact factor: 11.205
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