Literature DB >> 4525311

Amino-acid sequence of an allotype b4 light chain from a rabbit antibody to streptococcal carbohydrate.

K C Chen, T J Kindt, R M Krause.   

Abstract

The complete amino-acid sequence was determined for a rabbit-antibody light chain of allotype b4. The light chain was recovered from approximately 20 g of homogeneous antibody to group C streptococcal carbohydrate, which was obtained from an immunized rabbit. Several enzymic digestions were used to obtain the overlapping peptides necessary for the sequence determination. The L chain has 210 amino-acid residues, as determined by sequence analysis, and a molecular mass of 23,060 daltons. This antibody light chain contains seven half-cystine residues characteristic of the (kappa)B light-chain class. The amino-terminal sequence was determined to be Ala-Asp-Ile-Val-Met, indicating that the chain belongs to the V(kappa)I subgroup.

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Year:  1974        PMID： 4525311      PMCID： PMC388371          DOI： 10.1073/pnas.71.5.1995

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  19 in total

1.  Amino acid sequence around the epoxide-reactive residues in pepsin.

Authors:  K C Chen; J Tang
Journal:  J Biol Chem       Date:  1972-04-25       Impact factor: 5.157

2.  Specific cleavage between variable and constant domains of rabbit antibody light chains by dilute acid hydrolysis.

Authors:  K J Fraser; K Pulsen; E Haber
Journal:  Biochemistry       Date:  1972-12-19       Impact factor: 3.162

3.  Amino acid sequence of the light chain derived from a rabbit anti-p-azobenzoate antibody of restricted heterogeneity.

Authors:  E Appella; O A Roholt; A Chersi; G Radzimski; D Pressman
Journal:  Biochem Biophys Res Commun       Date:  1973-08-21       Impact factor: 3.575

4.  Intrachain disulphide bridges of rabbit immunoglobulin light chains of allotypes b4 and b5.

Authors:  M E Lamm; B Frangione
Journal:  Biochem J       Date:  1972-08       Impact factor: 3.857

5.  Variations at the carboxyl-terminal amino acid sequence of rabbit light chains with b4, b5 and b6 allotypic specificities.

Authors:  E Appella; J Rejnek; R A Reisfeld
Journal:  J Mol Biol       Date:  1969-05-14       Impact factor: 5.469

6.  Hydrolysis of phenylthiohydantoins of amino acids.

Authors:  H O Van Orden; F H Carpenter
Journal:  Biochem Biophys Res Commun       Date:  1964       Impact factor: 3.575

Review 7.  The search for antibodies with molecular uniformity.

Authors:  R M Krause
Journal:  Adv Immunol       Date:  1970       Impact factor: 3.543

8.  Isolation and characterization of electrophoretically homogeneous rabbit antihapten antibody populations. I. Separation and properties of homogeneous anti-p-azophenyltrimethyl-ammonium antibodies.

Authors:  M H Freedman; R H Painter
Journal:  J Biol Chem       Date:  1971-07-10       Impact factor: 5.157

9.  Separation of dansyl-amino acids by polyamide layer chromatography.

Authors:  K R Woods; K T Wang
Journal:  Biochim Biophys Acta       Date:  1967-02-21

10.  Relationships between relative binding affinity and electrophoretic behavior of rabbit antibodies to streptococcal carbohydrates.

Authors:  K Eichmann; J Greenblatt
Journal:  J Exp Med       Date:  1971-03-01       Impact factor: 14.307
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  12 in total

1.  Diversity of light chain variable region sequences among rabbit antibodies elicited by the same antigens.

Authors:  M N Margolies; L E Cannon; A D Strosberg; E Haber
Journal:  Proc Natl Acad Sci U S A       Date:  1975-06       Impact factor: 11.205

2.  Immunoglobulin allotypes of rabbit kappa chains: polymorphism of a control mechanism regulating closely linked duplicated genes?

Authors:  V Farnsworth; R Goodfliesh; S Rodkey; L Hood
Journal:  Proc Natl Acad Sci U S A       Date:  1976-04       Impact factor: 11.205

3.  cDNA clone encoding a complete rabbit immunoglobulin kappa light chain of b4 allotype.

Authors:  K L Dreher; L Emorine; T J Kindt; E E Max
Journal:  Proc Natl Acad Sci U S A       Date:  1983-07       Impact factor: 11.205

4.  Structural implications of sequence variability in immunoglobulins.

Authors:  E A Padlan
Journal:  Proc Natl Acad Sci U S A       Date:  1977-06       Impact factor: 11.205

5.  A comparison of the N-terminal amino acid sequences of early and late pools of anti-DNP and anti-DNP-p-aminobenzoylglutamate antibody light chains.

Authors:  D M Hagins; V H Bray; J Henke; R E Lovins
Journal:  Immunology       Date:  1978-05       Impact factor: 7.397

6.  Genetic Characterization of a new allele of the rabbit group b C(k) allotypes.

Authors:  J A Sogn; T J Kindt
Journal:  Immunogenetics       Date:  1978-12       Impact factor: 2.846

7.  Partial amino acid sequences of kappa-chains of rat immunoglobulins: genetic and evolutionary implications.

Authors:  A C Wang; H H Fudenberg; H Bazin
Journal:  Biochem Genet       Date:  1976-04       Impact factor: 1.890

8.  Rabbit immunoglobulin kappa genes: structure of a germline b4 allotype J-C locus and evidence for several b4-related sequences in the rabbit genome.

Authors:  L Emorine; K Dreher; T J Kindt; E E Max
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

9.  Nucleotide sequence of constant and 3' untranslated regions of a kappa immunoglobulin light chain mRNA of a homozygous b4 rabbit.

Authors:  O Heidmann; C Auffray; P A Cazenave; F Rougeon
Journal:  Proc Natl Acad Sci U S A       Date:  1981-09       Impact factor: 11.205

10.  Completion of the analysis of the primary structure of the variable domain of a homogeneous rabbit antibody to type III pneumococcal polysaccharide.

Authors:  J C Jaton
Journal:  Biochem J       Date:  1974-12       Impact factor: 3.857
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