Literature DB >> 4525284

A soluble super-active form of insulin.

T Oka, Y J Topper.   

Abstract

Insulin-like material can be extracted from insulin-Sepharose. This soluble material elicits super-insulin responses from mammary epithelial cells. It stimulates the accumulation of alpha-aminoisobutyric acid by virgin mouse mammary cells, which are unresponsive to insulin itself. It exerts a greater stimulatory effect on mammary cells from pregnant mice than insulin. It also is more efficacious than insulin as a stimulant of DNA synthesis and the combined activities of glucose-6-phosphate dehydrogenase (EC 1.1.1.49) and phosphogluconate dehydrogenase (EC 1.1.1.43). Its specific biological activity on these cells is more than five times greater than that of insulin.

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Year:  1974        PMID： 4525284      PMCID： PMC388290          DOI： 10.1073/pnas.71.5.1630

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  9 in total

1.  Cultivation of adult mouse mammary gland in hormone-enriched synthetic medium.

Authors:  J J ELIAS
Journal:  Science       Date:  1957-10-25       Impact factor: 47.728

2.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

3.  Studies on the mode of insulin: properties and biological activity of an insulin-dextran complex.

Authors:  F Suzuki; Y Daikuhara; N Ono; Y Takeda
Journal:  Endocrinology       Date:  1972-05       Impact factor: 4.736

4.  Insulin-sepharose and the dynamics of insulin action.

Authors:  T Oka; Y J Topper
Journal:  Proc Natl Acad Sci U S A       Date:  1971-09       Impact factor: 11.205

5.  The role of DNA synthesis and mitosis in hormone-dependent differentiation.

Authors:  F E Stockdale; Y J Topper
Journal:  Proc Natl Acad Sci U S A       Date:  1966-10       Impact factor: 11.205

6.  Hormone-dependent differentiation of mammary gland in vitro.

Authors:  W G Juergens; F E Stockdale; Y J Topper; J J Elias
Journal:  Proc Natl Acad Sci U S A       Date:  1965-08       Impact factor: 11.205

7.  Development of insulin-sensitivity by mouse mammary gland in vitro.

Authors:  S H Friedberg; T Oka; Y J Topper
Journal:  Proc Natl Acad Sci U S A       Date:  1970-11       Impact factor: 11.205

8.  Interaction of insulin with the cell membrane: the primary action of insulin.

Authors:  P Cuatrecasas
Journal:  Proc Natl Acad Sci U S A       Date:  1969-06       Impact factor: 11.205

9.  Increase in activity of glucose 6-phosphate dehydrogenase in mouse mammary tissue cultured in insulin.

Authors:  D P Leader; J M Barry
Journal:  Biochem J       Date:  1969-06       Impact factor: 3.857
  9 in total
  3 in total

1.  Re-evaluation of Sepharose-insulin as a tool for the study of insulin action.

Authors:  H J Kolb; R Renner; K D Hepp; L Weiss; O H Wieland
Journal:  Proc Natl Acad Sci U S A       Date:  1975-01       Impact factor: 11.205

2.  Protein-free cell culture on an artificial substrate with covalently immobilized insulin.

Authors:  Y Ito; J Zheng; Y Imanishi; K Yonezawa; M Kasuga
Journal:  Proc Natl Acad Sci U S A       Date:  1996-04-16       Impact factor: 11.205

3.  Structure of a soluble super-active insulin is revealed by the nature of the complex between cyanogen-bromide-activated sepharose and amines.

Authors:  M Wilchek; T Oka; Y J Topper
Journal:  Proc Natl Acad Sci U S A       Date:  1975-03       Impact factor: 11.205
  3 in total

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