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Literature DB >> 4517676

Synthesis of the myoglobin active site.

Abstract

A simple heme-imidazole compound, having the same geometry as the heme-imidazole complex in myoglobin, has been synthesized. This compound, ferropyrroporphyrin-N-[3-(1-imidazolyl)propyl]amide, reversibly binds oxygen in the solid state or when dissolved in a polystyrene film. These results suggest that the principal factors governing reversible oxygen binding are the electronic nature of the base (imidazole), neighboring-group effects of the basic group, and immobilization of the heme group.

Entities: Chemical

Mesh：

Substances：

Year: 1973 PMID： 4517676 PMCID： PMC427074 DOI： 10.1073/pnas.70.9.2647

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

11 in total

Review 1. THE HEMOGLOBINS.

Authors: G BRAUNITZER; K HILSE; V RUDLOFF; N HILSCHMANN
Journal: Adv Protein Chem Date: 1964

Review 2. HEMOGLOBIN AND MYOGLOBIN.

Authors: A ROSSIFANELLI; E ANTONINI; A CAPUTO
Journal: Adv Protein Chem Date: 1964

3. [On organic catalysts. 67. The catalytic activation of hemin by histidine derivatives and histidine peptides].

Authors: G LOSSE; G MUELLER
Journal: Hoppe Seylers Z Physiol Chem Date: 1962-05-04

4. Thermodynamics of the reversible oxygenation of N,N-ethylene bis (salicylideneiminato) cobalt(II) in pyridine.

Authors: G Tauzher; G Amiconi; E Antonini; M Brunori; G Costa
Journal: Nat New Biol Date: 1973-02-14

5. Kinetics of the reaction of amine complexes of cobalt(II) protoporphyrin IX dimethyl ester with oxygen. Evidence for hydrogen bonding with coordinated oxygen.

Authors: D V Stynes; H C Stynes; J A Ibers; B R James
Journal: J Am Chem Soc Date: 1973-02-21 Impact factor: 15.419

6. Cyclophane porphyrin.

Authors: H Dickmann; C K Chang; T G Traylor
Journal: J Am Chem Soc Date: 1971-08-11 Impact factor: 15.419

7. Stereochemistry of cooperative effects in haemoglobin.

Authors: M F Perutz
Journal: Nature Date: 1970-11-21 Impact factor: 49.962

8. Substituted deuteroporphyrins. I. Reactions at the periphery of the porphyrin ring.

Authors: W S Caughey; J O Alben; W Y Fujimoto; J L York
Journal: J Org Chem Date: 1966-08 Impact factor: 4.354

9. Reactions of monomeric cobalt-oxygen complexes. I. Thermodynamics of reaction of molecular oxygen with five- and six-coordinate amine complexes of a cobalt porphyrin.

Authors: F A Walker
Journal: J Am Chem Soc Date: 1973-02-21 Impact factor: 15.419

10. Heme sulfuric anhydrides. II. Properties of heme models prepared from mesoheme sulfuric anhydrides.

Authors: P K Warme; L P Hager
Journal: Biochemistry Date: 1970-03-31 Impact factor: 3.162

5 in total

1. The H93G Myoglobin Cavity Mutant as a Versatile Scaffold for Modeling Heme Iron Coordination Structures in Protein Active Sites and Their Characterization with Magnetic Circular Dichroism Spectroscopy.

Authors: Jing Du; Masanori Sono; John H Dawson
Journal: Coord Chem Rev Date: 2011-04-01 Impact factor: 22.315