Literature DB >> 4509331

Occurrence of uridylate-rich oligonucleotide regions in heterogeneous nuclear RNA of HeLa cells.

G R Molloy, W L Thomas, J E Darnell.   

Abstract

Heterogeneous nuclear RNA molecules from HeLa cells contain a specific segment of about 30 nucleotides length that is largely (about 80%) uridylic acid. This oligo(U) segment is located predominantly in the larger (70S-90S) heterogeneous nuclear RNA molecules, and is essentially absent in messenger RNA and 45S ribosomal precursor RNA molecules. The oligo(U) hybridizes rapidly to cellular DNA, suggesting that it is transcribed from the repeated regions of the DNA.

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Year:  1972        PMID： 4509331      PMCID： PMC389849          DOI： 10.1073/pnas.69.12.3684

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  30 in total

1.  Double-stranded regions in heterogeneous nuclear RNA from Hela cells.

Authors:  W Jelinek; J E Darnell
Journal:  Proc Natl Acad Sci U S A       Date:  1972-09       Impact factor: 11.205

2.  Addition of polyadenylate sequences to virus-specific RNA during adenovirus replication.

Authors:  L Philipson; R Wall; G Glickman; J E Darnell
Journal:  Proc Natl Acad Sci U S A       Date:  1971-11       Impact factor: 11.205

3.  Fractionation of heterogeneous nuclear RNA: rates of hybridization and chromosomal distribution of reiterated sequences.

Authors:  G N Pagoulatos; J E Darnell
Journal:  J Mol Biol       Date:  1970-12-28       Impact factor: 5.469

4.  The isolation and characterization of adenosine monophosphate-rich polynucleotides synthesized by Ehrlich ascites cells.

Authors:  M Edmonds; M G Caramela
Journal:  J Biol Chem       Date:  1969-03-10       Impact factor: 5.157

5.  Rapidly labeled, polyribosome-associated RNA having the properties of histone messenger.

Authors:  T W Borun; M D Scharff; E Robbins
Journal:  Proc Natl Acad Sci U S A       Date:  1967-11       Impact factor: 11.205

6.  High molecular weight nonribosomal-type nuclear RNA and cytoplasmic messenger RNA in HeLa cells.

Authors:  J F Houssais; G Attardi
Journal:  Proc Natl Acad Sci U S A       Date:  1966-08       Impact factor: 11.205

7.  The ribonuclease activity of crystallized pancreatic deoxyribonuclease.

Authors:  S B Zimmerman; D Sandeen
Journal:  Anal Biochem       Date:  1966-02       Impact factor: 3.365

8.  Rapidly labeled HeLa cell nuclear RNA. I. Identification by zone sedimentation of a heterogeneous fraction separate from ribosomal precursor RNA.

Authors:  J R Warner; R Soeiro; H C Birnboim; M Girard; J E Darnell
Journal:  J Mol Biol       Date:  1966-08       Impact factor: 5.469

9.  Studies on extracellular ribonucleases of Ustilago sphaerogena. Characterization of substrate specificity with special reference to purine-specific ribonucleases.

Authors:  T Arima; T Uchida; F Egami
Journal:  Biochem J       Date:  1968-02       Impact factor: 3.857

10.  Physical and chemical characterization of two- and three-stranded adenine-thymine and adenine-uracil homopolymer complexes.

Authors:  M Riley; B Maling
Journal:  J Mol Biol       Date:  1966-09       Impact factor: 5.469
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  16 in total

1.  Hybridization of polyuridylic acid to human DNA immobilized onto nitrocellulose filters.

Authors:  R W Pero; T Bryngelsson; C Bryngelsson; A Deutsch; A Nordén; A Norgren
Journal:  Nucleic Acids Res       Date:  1975-07       Impact factor: 16.971

2.  Two classes of translational control RNA: their role in the regulation of protein synthesis.

Authors:  A J Bester; D S Kennedy; S M Heywood
Journal:  Proc Natl Acad Sci U S A       Date:  1975-04       Impact factor: 11.205

3.  The binding of poly (rA) and poly (rU) to denatured DNA. II. Studies with natural DNAs.

Authors:  J N Mol; P Borst
Journal:  Nucleic Acids Res       Date:  1976-04       Impact factor: 16.971

4.  Preparation and properties of a poly A resin and its use in the isolation of naturally occurring poly U sequences.

Authors:  S Venkatesan; H Nakazato; M Edmonds
Journal:  Nucleic Acids Res       Date:  1976-08       Impact factor: 16.971

5.  Oligouridylate stretches in heterogeneous nuclear RNA.

Authors:  L M Dubroff
Journal:  Proc Natl Acad Sci U S A       Date:  1977-06       Impact factor: 11.205

6.  Differential metabolism of large and small poly(A) sequences in the heterogeneous nuclear RNA of HeLa cells.

Authors:  H Nakazato; M Edmonds; D W Kopp
Journal:  Proc Natl Acad Sci U S A       Date:  1974-01       Impact factor: 11.205

7.  In vitro synthesis of RNA that contains polyadenylate by virion-associated RNA polymerase of vesicular stomatitis virus.

Authors:  A K Banerjee; D P Rhodes
Journal:  Proc Natl Acad Sci U S A       Date:  1973-12       Impact factor: 11.205

8.  Demonstration of globin messenger sequences in giant nuclear precursors of messenger RNA of avian erythroblasts.

Authors:  T Imaizumi; H Diggelmann; K Scherrer
Journal:  Proc Natl Acad Sci U S A       Date:  1973-04       Impact factor: 11.205

9.  Poly(A) polymerase activity in reovirus.

Authors:  C M Stoltzfus; M Morgan; A K Banerjee; A J Shatkin
Journal:  J Virol       Date:  1974-06       Impact factor: 5.103

10.  Analysis of long pyrimidine polynucleotides in HeLa cell nuclear DNA: absence of polydeoxythymidylate.

Authors:  H C Birnboim; R E Mitchel; N A Straus
Journal:  Proc Natl Acad Sci U S A       Date:  1973-08       Impact factor: 11.205
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