Literature DB >> 4504364

Distinction between the preneoplastic and neoplastic state of murine mammary glands.

C F Hazelwood, D C Chang, D Medina, G Cleveland, B L Nichols.   

Abstract

We have, using nuclear magnetic resonance spectroscopy, measured the relaxation times and diffusion coefficient of water protons in primary mammary adenocarcinomas of mice. In our biological model, three morphological stages were defined: (a) mammary gland tissue from pregnant mice, (b) preneoplastic nodules, and (c) neoplastic tissue. It was found that neoplastic tissues could be distinguished from normal and prenoeplastic tissue. Spin-spin and spin-lattice relaxation times and the diffusion coefficient of water protons are increased in the neoplastic tissue relative to mammary gland tissue from pregnant mice and preneoplastic nodule tissue.

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Year:  1972        PMID： 4504364      PMCID： PMC426730          DOI： 10.1073/pnas.69.6.1478

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  11 in total

1.  Some characteristics of the preneoplastic hyperplastic alveolar nodules of C3H/Crgl mice.

Authors:  K B DEOME; P B BLAIR; L J FAULKIN
Journal:  Acta Unio Int Contra Cancrum       Date:  1961

2.  Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice.

Authors:  K B DEOME; L J FAULKIN; H A BERN; P B BLAIR
Journal:  Cancer Res       Date:  1959-06       Impact factor: 12.701

3.  The state of water in polarized and depolarized frog nerves a proton magnetic resonance study.

Authors:  O G Fritz; T J Swift
Journal:  Biophys J       Date:  2008-12-31       Impact factor: 4.033

4.  Effects of various oncogenic agents on tumor-producing capabilities of series D BALB-c mammary nodule outgrowth lines.

Authors:  D Medina; K B DeOme
Journal:  J Natl Cancer Inst       Date:  1970-08       Impact factor: 13.506

5.  Biology and pathology of water.

Authors:  A Szent-Györgyi
Journal:  Perspect Biol Med       Date:  1971       Impact factor: 1.416

6.  A proton spin-echo study of the state of water in frog nerves.

Authors:  T J Swift; O G Fritz
Journal:  Biophys J       Date:  1969-01       Impact factor: 4.033

7.  Evidence for the existence of a minimum of two phases of ordered water in skeletal muscle.

Authors:  C F Hazlewood; B L Nichols; N F Chamberlain
Journal:  Nature       Date:  1969-05-24       Impact factor: 49.962

8.  On the state of water in developing muscle: a study of the major phase of ordered water in skeletal muscle and its relationship to sodium concentration.

Authors:  C F Hazlewood; B L Nichols; D C Chang; B Brown
Journal:  Johns Hopkins Med J       Date:  1971-03

9.  Nuclear magnetic resonance evidence using D2O for structured water in muscle and brain.

Authors:  F W Cope
Journal:  Biophys J       Date:  1969-03       Impact factor: 4.033

10.  Tumor detection by nuclear magnetic resonance.

Authors:  R Damadian
Journal:  Science       Date:  1971-03-19       Impact factor: 47.728
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  21 in total

1.  A ROLE FOR WATER IN THE EXCLUSION OF CELLULAR SODIUM-IS A SODIUM PUMP NEEDED?

Authors:  Carlton F. Hazlewood
Journal:  Cardiovasc Dis       Date:  1975

2.  Changes of tissue water proton relaxation rates during early phases of chemical carcinogenesis.

Authors:  R A Floyd; T Yoshida; J S Leigh
Journal:  Proc Natl Acad Sci U S A       Date:  1975-01       Impact factor: 11.205

3.  Nuclear magnetic resonance study of mammalian cell water influence of water content and ionic environment.

Authors:  G P Raaphorst; J Kruuv; M M Pintar
Journal:  Biophys J       Date:  2009-01-01       Impact factor: 4.033

4.  NMR relaxation study of water protons in Syrian hamster fetal cells at 300 MHz.

Authors:  W J Xin; S A Bruce; S F Deamond; L S Kan; J Honarbakhsh; P O Ts'o
Journal:  Cell Biophys       Date:  1986-06

5.  Quantification of Nonenhancing Tumor Burden in Gliomas Using Effective T2 Maps Derived from Dual-Echo Turbo Spin-Echo MRI.

Authors:  Benjamin M Ellingson; Albert Lai; Huytram N Nguyen; Phioanh L Nghiemphu; Whitney B Pope; Timothy F Cloughesy
Journal:  Clin Cancer Res       Date:  2015-04-21       Impact factor: 12.531

6.  Nuclear magnetic resonance measurement of skeletal muscle: anisotrophy of the diffusion coefficient of the intracellular water.

Authors:  G G Cleveland; D C Chang; C F Hazlewood; H E Rorschach
Journal:  Biophys J       Date:  1976-09       Impact factor: 4.033

7.  The Biophysical Society of Hong Kong (BPHK): past, present, and future.

Authors:  Guang Zhu
Journal:  Biophys Rev       Date:  2019-05-04

Review 8.  Translating preclinical MRI methods to clinical oncology.

Authors:  David A Hormuth; Anna G Sorace; John Virostko; Richard G Abramson; Zaver M Bhujwalla; Pedro Enriquez-Navas; Robert Gillies; John D Hazle; Ralph P Mason; C Chad Quarles; Jared A Weis; Jennifer G Whisenant; Junzhong Xu; Thomas E Yankeelov
Journal:  J Magn Reson Imaging       Date:  2019-03-29       Impact factor: 4.813

9.  In vivo 31P NMR study of the metabolism of murine mammary 16/C adenocarcinoma and its response to chemotherapy, x-radiation, and hyperthermia.

Authors:  W T Evanochko; T C Ng; M B Lilly; A J Lawson; T H Corbett; J R Durant; J D Glickson
Journal:  Proc Natl Acad Sci U S A       Date:  1983-01       Impact factor: 11.205

10.  Water permeability changes studied by 17O nuclear magnetic resonance during differentiation of Friend leukemia cells.

Authors:  N Haran; Z Malik; A Lapidot
Journal:  Proc Natl Acad Sci U S A       Date:  1979-07       Impact factor: 11.205
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