Literature DB >> 4477565

Effect of DDS on phytohemagglutinin-induced lymphocyte transformation.

B Beiguelman, R C Pisam.   

Abstract

The influence of DDS on PHA-induced lymphocyte transformation was investigated in leukocyte cultures from two samples of healthy Caucasoid individuals. In one sample the sulfone-treated cultures differed from the controls in that they contained 0.4 mug/ml of other sample, the treated cultures contained DDS in concentrations of 4 mug/ml, 8 mug/ml and 16 mug/ml. The frequency of lymphocyte transformation induced by PHA was significantly reduced by DDS in all concentrations used. The data obtained are a strong indication that the plasma levels of dapsone among leprosy patients may contribute to the depression of the blastogenic capacity of their lymphocytes when stimulated by PHA.

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Year:  1974        PMID： 4477565

Source DB:  PubMed          Journal:  Int J Lepr Other Mycobact Dis        ISSN： 0148-916X


  6 in total

1.  Dapsone as an Immunomodulator In Vivo Using the Tuberculin Skin Test as a Parameter.

Authors:  J R Snyman; W K Jacyk; D J Lizamore; K De Sommers
Journal:  Clin Drug Investig       Date:  1995-09       Impact factor: 2.859

Review 2.  Dapsone in dermatology and beyond.

Authors:  Gottfried Wozel; Christian Blasum
Journal:  Arch Dermatol Res       Date:  2013-12-06       Impact factor: 3.017

3.  Dermatitis herpetiformis: effects of sulfones and sulfonamides on neutrophil myeloperoxidase-mediated iodination and cytotoxicity.

Authors:  J A Kazmierowski; J E Ross; D S Peizner; K D Wuepper
Journal:  J Clin Immunol       Date:  1984-01       Impact factor: 8.317

4.  Acantholysis produced in vitro with pemphigus serum: hydrocortisone inhibits acantholysis, while dapsone and 6-mercaptopurine do not inhibit acantholysis.

Authors:  E W Jeffes; R P Kaplan; A R Ahmed
Journal:  J Clin Immunol       Date:  1984-09       Impact factor: 8.317

5.  Defect in the generation of cytotoxic T cells in lepromatous leprosy.

Authors:  J L Stach; M Strobel; F Fumoux; J F Bach
Journal:  Clin Exp Immunol       Date:  1982-06       Impact factor: 4.330

6.  Effects of dapsone on passive Arthus reaction and chemotaxis and phagocytosis of polymorphonuclear leukocytes.

Authors:  T Ruzicka; A Bauer; S Glück; M Born
Journal:  Arch Dermatol Res       Date:  1981       Impact factor: 3.017
  6 in total

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