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Literature DB >> 6214342

Defect in the generation of cytotoxic T cells in lepromatous leprosy.

J L Stach, M Strobel, F Fumoux, J F Bach.

Abstract

Cytotoxic T cells are consistently produced in normal individuals after in vitro stimulation by a pool of mitomycin-treated normal lymphocytes. Patients suffering from lepromatous leprosy (LL), presenting with large amounts of Mycobacterium leprae and without a history of erythema nodosum leprosum (ENL) are unable to generate such cytotoxic T cells, while lepromatous patients with ENL which, in the present study were all deprived of M. leprae, react normally.

Entities: Chemical Disease Species

Mesh：

Year: 1982 PMID： 6214342 PMCID： PMC1536602

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

35 in total

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Authors: J N Sheagren; J B Block; J R Trautman; S M Wolff
Journal: Ann Intern Med Date: 1969-02 Impact factor: 25.391

2. Prolonged survival of skin allografts in leprosy patients.

Authors: S H Han; R S Weiser; S T Kau
Journal: Int J Lepr Other Mycobact Dis Date: 1971 Jan-Mar

3. Production of macrophage inhibitory factor by patients with leprosy.

Authors: S I Katz; B H DeBetz; N Zaias
Journal: Arch Dermatol Date: 1971-04

4. Significance of variations within the lepromatous group.

Authors: D S Ridley; M F Waters
Journal: Lepr Rev Date: 1969-07 Impact factor: 0.537

5. Immunologic suppression in leprosy and its relation to lepromatous disease.

Authors: C C Shepard
Journal: Int J Lepr Other Mycobact Dis Date: 1968 Jan-Mar

6. Phytohaemagglutinin-induced lymphocyte transformation in leprosy.

Authors: D S Nelson; M Nelson; J M Thurston; M F Waters; J M Pearson
Journal: Clin Exp Immunol Date: 1971-07 Impact factor: 4.330

7. [Study ofn leprosy immunity].

Authors: M Salazar Mallén; A Chévez Zamora; J Montes Montes; A Escobar; D Mitrani Levy; M E Amezcua
Journal: Alergia Date: 1971-05

8. Studies on T cell subsets and functions in leprosy.

Authors: M A Bach; L Chatenoud; D Wallach; F Phan Dinh Tuy; F Cottenot
Journal: Clin Exp Immunol Date: 1981-06 Impact factor: 4.330

9. Studies of immune mechanisms in leprosy. 3. The role of cellular and humoral factors in impairment of the in vitro immune response.

Authors: W E Bullock; P Fasal
Journal: J Immunol Date: 1971-04 Impact factor: 5.422

10. Classification of leprosy according to immunity. A five-group system.

Authors: D S Ridley; W H Jopling
Journal: Int J Lepr Other Mycobact Dis Date: 1966 Jul-Sep

6 in total

Review 1. T cell and cytokine patterns in leprosy skin lesions.

Authors: P A Sieling; R L Modlin
Journal: Springer Semin Immunopathol Date: 1992

2. Epidermal keratinocyte Ia expression, Langerhans cell hyperplasia and lymphocytic infiltration in skin lesions of leprosy.

Authors: T H Rea; J Y Shen; R L Modlin
Journal: Clin Exp Immunol Date: 1986-08 Impact factor: 4.330