Literature DB >> 4476225

The effect of receptor desensitization on the action of alpha-bungaro-toxin on cultured skeletal muscle.

W F Dryden, A L Harvey.   

Abstract

The effect of receptor desensitization produced by carbachol on the antagonist action of alpha-bungarotoxin has been studied in cultured skeletal muscle from chick embryos. In control preparations, alpha-bungarotoxin irreversibly blocked depolarization produced by carbachol. However, after receptor desensitization, alpha-bungarotoxin was no longer effective in blocking the response to carbachol. It is concluded that desensitization protects cholinoceptors from the action of alpha-bungarotoxin.

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Year:  1974        PMID： 4476225      PMCID： PMC1776764          DOI： 10.1111/j.1476-5381.1974.tb10683.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  13 in total

Review 1.  Chemistry and pharmacology of polypeptide toxins in snake venoms.

Authors:  C Y Lee
Journal:  Annu Rev Pharmacol       Date:  1972       Impact factor: 13.820

2.  Acetylcholine receptors in muscle fibres.

Authors:  R Miledi; L T Potter
Journal:  Nature       Date:  1971-10-29       Impact factor: 49.962

3.  Acetylcholine receptors of muscle grown in vitro.

Authors:  Z Vogel; A J Sytkowski; M W Nirenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1972-11       Impact factor: 11.205

4.  A physiological study of chick myotubes grown in tissue culture.

Authors:  J B Harris; M W Marshall; P Wilson
Journal:  J Physiol       Date:  1973-03       Impact factor: 5.182

5.  Acetycholine receptor production and incorporation into membranes of developing muscle fibers.

Authors:  H C Hartzell; D M Fambrough
Journal:  Dev Biol       Date:  1973-01       Impact factor: 3.582

6.  Vulnerability of desensitized or curare-treated acetylcholine receptors to irreversible blockade by cobra toxin.

Authors:  H A Lester
Journal:  Mol Pharmacol       Date:  1972-11       Impact factor: 4.436

7.  On the mechanism of desensitization at cholinergic receptors.

Authors:  H P Rang; J M Ritter
Journal:  Mol Pharmacol       Date:  1970-07       Impact factor: 4.436

8.  Synaptic potentials recorded in cell cultures of nerve and muscle.

Authors:  G D Fischbach
Journal:  Science       Date:  1970-09-25       Impact factor: 47.728

9.  Development of acetylcholine sensitivity in cultured skeletal muscle.

Authors:  W F Dryden
Journal:  Experientia       Date:  1970-09-26

10.  Appearance of acetylcholine receptors during differentiation of a myogenic cell line.

Authors:  J Patrick; S F Heinemann; J Lindstrom; D Schubert; J H Steinbach
Journal:  Proc Natl Acad Sci U S A       Date:  1972-10       Impact factor: 11.205
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  1 in total

1.  Regulation of acetylcholine receptor levels by a cholinergic agonist in mouse muscle cell cultures.

Authors:  M D Noble; T H Brown; J H Peacock
Journal:  Proc Natl Acad Sci U S A       Date:  1978-07       Impact factor: 11.205
  1 in total

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