Literature DB >> 4474904

Effects of catecholamine synthesis inhibition on ethanol-induced withdrawal symptoms in mice.

K Blum, J E Wallace.   

Abstract

alpha-Methyl-p-tyrosine, a catecholamine synthesis inhibitor, was studied to determine its effects against ethanol-induced withdrawal symptoms in mice. Signifilcant (P < 0.001) potentiation of the withdrawal convulsion score induced by ethanol vapour exposure for three days was observed in mice. The synergistic effect was not due to alteration of ethanol metabolism. These results indicate that reductions in catecholamines (dopamine and noradrenaline) augment seizure activity induced by subchronic exposure to ethanol.

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Year:  1974        PMID： 4474904      PMCID： PMC1776830          DOI： 10.1111/j.1476-5381.1974.tb09640.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  8 in total

1.  LIVER ALCOHOL DEHYDROGENASE-DPN-PYRAZOLE COMPLEX: A MODEL OF A TERNARY INTERMEDIATE IN THE ENZYME REACTION.

Authors:  H THEORELL; T YONETANI
Journal:  Biochem Z       Date:  1963

2.  Genetics of audiogenic seizures: II. Effects of pharmacological manipulation of brain serotonin, norepinephrine and gamma-aminobutyric acid.

Authors:  K Schlesinger; W Boggan; D X Freedman
Journal:  Life Sci       Date:  1968-04-01       Impact factor: 5.037

3.  An animal model for testing effects of drugs on alcohol withdrawal reactions.

Authors:  D B Goldstein
Journal:  J Pharmacol Exp Ther       Date:  1972-10       Impact factor: 4.030

4.  Pyrazole and ethanol potentiation of tryptophol-induced sleep in mice.

Authors:  A Feldstein; J M Kurcharski
Journal:  Life Sci I       Date:  1971-09-01

5.  Evidence of a role for brain monoamines in ethanol dependence.

Authors:  P J Griffiths; J M Littleton; A Oritz; G Brownlee
Journal:  Br J Pharmacol       Date:  1973-06       Impact factor: 8.739

6.  Effects of catecholamine synthesis inhibition on ethanol narcosis in mice.

Authors:  K Blum; J H Merritt; J E Wallace; R Owen; J W Hahn; I Geller
Journal:  Curr Ther Res Clin Exp       Date:  1972-06

7.  Alcohol dependence produced in mice by inhalation of ethanol: grading the withdrawal reaction.

Authors:  D B Goldstein; N Pal
Journal:  Science       Date:  1971-04-16       Impact factor: 47.728

8.  Alcohol, amines, and alkaloids: a possible biochemical basis for alcohol addiction.

Authors:  V E Davis; M J Walsh
Journal:  Science       Date:  1970-02-13       Impact factor: 47.728
  8 in total
  2 in total

1.  Biochemical investigations into the alcoholic delirium: alterations of biogenic amines.

Authors:  D Athen; H Beckmann; M Ackenheil; M Markianos
Journal:  Arch Psychiatr Nervenkr (1970)       Date:  1977-10-11

2.  Effects of drugs affecting endogenous amines or cyclic nucleotides on ethanol withdrawal head twitches in mice.

Authors:  H O Collier; M D Hammond; C Schneider
Journal:  Br J Pharmacol       Date:  1976-09       Impact factor: 8.739
  2 in total

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