Literature DB >> 446661

Comparative studies on the covalent binding of the carcinogen benzo(a)pyrene to DNA in various model systems.

W Jaggi, W K Lutz, C Schlatter.   

Abstract

The covalent binding of tritiated benzo(a)pyrene (BP) to DNA has been determined in rat liver in vivo, in rat liver perfused in situ, after incubation of BP with liver single cells, with liver homogenate, with liver microsomes and DNA, with fibroblasts from a rat granuloma pouch, and with 2 cell lines. Liver single cells were found to be a valuable compromise between the most sensitive system (microsomal incubation of BP and DNA) and the biologically most relevant system (in vivo).

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Year:  1979        PMID： 446661     DOI： 10.1007/bf01960365

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  8 in total

Review 1.  Chemical carcinogenesis.

Authors:  C Heidelberger
Journal:  Annu Rev Biochem       Date:  1975       Impact factor: 23.643

Review 2.  Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.

Authors:  J A Miller
Journal:  Cancer Res       Date:  1970-03       Impact factor: 12.701

3.  Hydroxyapatite column chromatography in procedures for isolation of purified DNA.

Authors:  G G Markov; I G Ivanov
Journal:  Anal Biochem       Date:  1974-06       Impact factor: 3.365

4.  Time course of the induction of aryl hydrocarbon hydroxylase in rat liver nuclei and microsomes by phenobarbital, 3-methylcholanthrene, 2,3,7,8-tetrachloro-dibenzo-p-dioxin, dieldrin and other inducers.

Authors:  A Viviani; W K Lutz; C Schlatter
Journal:  Biochem Pharmacol       Date:  1978       Impact factor: 5.858

5.  Non-enzymatic and microsome-dependent binding of poly-cyclic hydrocarbons to DNA and polynucleotides.

Authors:  S Grilli; P Rocchi; G Prodi
Journal:  Chem Biol Interact       Date:  1975-11       Impact factor: 5.192

6.  Nonlinear dose-response relationship for the binding of the carcinogen benzo(a)pyrene to rat liver DNA in vivo.

Authors:  W K Lutz; A Viviant; C Schlatter
Journal:  Cancer Res       Date:  1978-03       Impact factor: 12.701

7.  Granuloma pouch assay. I. Induction of ouabain resistance by MNNG in vivo.

Authors:  P Maier; P Manser; G Zbinden
Journal:  Mutat Res       Date:  1978-10       Impact factor: 2.433

8.  High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.

Authors:  M N Berry; D S Friend
Journal:  J Cell Biol       Date:  1969-12       Impact factor: 10.539
  8 in total
  2 in total

1.  Covalent binding of drug metabolites to DNA--a tool of predictive value?

Authors:  H M Bolt; R J Laib
Journal:  Arch Toxicol       Date:  1980-11       Impact factor: 5.153

2.  Quantitative predictability of carcinogenicity of the covalent binding index of chemicals to DNA: comparison of the in vivo and in vitro assays.

Authors:  M Taningher; G Saccomanno; L Santi; S Grilli; S Parodi
Journal:  Environ Health Perspect       Date:  1990-03       Impact factor: 9.031
  2 in total

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