Literature DB >> 4462556

Subcellular distribution and properties of kynurenine transaminase in rat liver.

M Nakatani, M Morimoto, T Noguchi, R Kido.   

Abstract

Kynurenine transaminase activity in rat liver was found in both the mitochondrial and supernatant fractions. The mitochondrial and supernatant fractions contained (a) kynurenine-pyruvate transaminase, which showed a preference for pyruvate as amino acceptor and a pH optimum between 8.0 and 8.5, and (b) kynurenine-alpha-oxoglutarate transaminase, with a preference for alpha-oxoglutarate and a pH optimum between 6.0 and 6.5. Possible roles of these enzymes in tryptophan metabolism in the liver are discussed.

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Year:  1974        PMID： 4462556      PMCID： PMC1168385          DOI： 10.1042/bj1430303

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  20 in total

1.  Kynurenine-transaminase, kynureninase and the increase of xanthurenic acid excretion.

Authors:  N OGASAWARA; Y HAGINO; Y KOTAKE
Journal:  J Biochem       Date:  1962-09       Impact factor: 3.387

2.  Direct spectrophotometric studies of the kinetics of oxidation and reduction of ubiquinone of heart-muscle particles.

Authors:  B CHANCE; E R REDFEARN
Journal:  Biochem J       Date:  1961-09       Impact factor: 3.857

3.  Kynurenine transaminase of rat kidney; a study of coenzyme dissociation.

Authors:  M MASON
Journal:  J Biol Chem       Date:  1957-07       Impact factor: 5.157

4.  Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue.

Authors:  C DE DUVE; B C PRESSMAN; R GIANETTO; R WATTIAUX; F APPELMANS
Journal:  Biochem J       Date:  1955-08       Impact factor: 3.857

5.  The kynurenine transaminase of rat kidney.

Authors:  M MASON
Journal:  J Biol Chem       Date:  1954-12       Impact factor: 5.157

6.  The relation of liver kynureninase to tryptophan metabolism in pyridoxine deficiency.

Authors:  W E KNOX
Journal:  Biochem J       Date:  1953-02       Impact factor: 3.857

7.  The conversion of tryptophan to kynurenine in liver. II. The enzymatic hydrolysis of formylkynurenine.

Authors:  A H MEHLER; W E KNOX
Journal:  J Biol Chem       Date:  1950-11       Impact factor: 5.157

8.  Solubilization and partial purification of kynurenine hydroxylase from mitochondrial outer membrane and its electron donors.

Authors:  H Okamoto; O Hayaishi
Journal:  Arch Biochem Biophys       Date:  1969-05       Impact factor: 4.013

9.  Intramitochondrial localization of kynurenine aminotransferase.

Authors:  H Okamoto; O Hayaishi
Journal:  J Biol Chem       Date:  1970-07-25       Impact factor: 5.157

10.  The submitochondrial localization of monoamine oxidase. An enzymatic marker for the outer membrane of rat liver mitochondria.

Authors:  C Schnaitman; V G Erwin; J W Greenawalt
Journal:  J Cell Biol       Date:  1967-03       Impact factor: 10.539
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  6 in total

1.  Organ distribution of rat histidine-pyruvate aminotransferase isoenzymes.

Authors:  T Noguchi; Y Minatogawa; E Okuno; R Kido
Journal:  Biochem J       Date:  1976-09-01       Impact factor: 3.857

2.  A mathematical model of tryptophan metabolism via the kynurenine pathway provides insights into the effects of vitamin B-6 deficiency, tryptophan loading, and induction of tryptophan 2,3-dioxygenase on tryptophan metabolites.

Authors:  Luisa Rios-Avila; H Frederik Nijhout; Michael C Reed; Harry S Sitren; Jesse F Gregory
Journal:  J Nutr       Date:  2013-07-31       Impact factor: 4.798

3.  Purification and characterization of kynurenine--2-oxoglutarate aminotransferase from the liver, brain and small intestine of rats.

Authors:  T Noguchi; Y Minatogawa; E Okuno; M Nakatani; M Morimoto
Journal:  Biochem J       Date:  1975-11       Impact factor: 3.857

4.  Purification and properties of 2-aminoadipate: 2-oxoglutarate aminotransferase from bovine kidney.

Authors:  D R Deshmukh; S M Mungre
Journal:  Biochem J       Date:  1989-08-01       Impact factor: 3.857

5.  Purification and properties of kynurenine aminotransferase from rat kidney.

Authors:  M R Mawal; A Mukhopadhyay; D R Deshmukh
Journal:  Biochem J       Date:  1991-10-15       Impact factor: 3.857

6.  Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women.

Authors:  Vanessa R da Silva; Luisa Rios-Avila; Yvonne Lamers; Maria A Ralat; Øivind Midttun; Eoin P Quinlivan; Timothy J Garrett; Bonnie Coats; Meena N Shankar; Susan S Percival; Yueh-Yun Chi; Keith E Muller; Per Magne Ueland; Peter W Stacpoole; Jesse F Gregory
Journal:  J Nutr       Date:  2013-08-21       Impact factor: 4.798
  6 in total

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