Literature DB >> 44446

N-demethylation of lergotrile by Streptomyces platensis.

P J Davis, J C Glade, A M Clark, R V Smith.   

Abstract

Thirty-eight microorganisms were screened for their ability to produce metabolites of the semisynthetic alkaloid, lergotrile. A total of five microorganisms were found to biotransform lergotrile, and N-desmethyl lergotrile was detected as the principal metabolite with most organisms. Streptomyces platensis (NRRL 2364) appeared to form the metabolite in highest yield, and a preparative-scale conversion was accomplished with a recovered yield of 50%. Structure proof was accomplished with comparative thin-layer chromatography, mixed melting point, mass spectrometry, and remethylation to lergotrile.

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Year:  1979        PMID： 44446      PMCID： PMC243604          DOI： 10.1128/aem.38.5.891-893.1979

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  9 in total

1.  Microbial models of mammalian metabolism.

Authors:  R V Smith; J P Rosazza
Journal:  J Pharm Sci       Date:  1975-11       Impact factor: 3.534

2.  Studies on the antiparkinsonism efficacy of lergotrile.

Authors:  A Lieberman; T Miyamoto; A F Battista; M Goldstein
Journal:  Neurology       Date:  1975-05       Impact factor: 9.910

3.  Metabolism of lergotrile to 13-hydroxy lergotrile, a potent inhibitor of prolactin release in vitro.

Authors:  C J Parli; B Schmidt; C J Shaar
Journal:  Biochem Pharmacol       Date:  1978-05-01       Impact factor: 5.858

4.  The pathophysiology of hyperprolactinemic states and the role of newer ergot compounds in their treatment.

Authors:  A G Frantz; D L Kleinberg
Journal:  Fed Proc       Date:  1978-06

5.  The isolation and structural elucidation of liatrin, a novel antileukemic sesquiterpene lactone from Liatris chapmanii.

Authors:  S M Kupchan; V H Davies; T Fujita; M R Cox; R J Restivo; R F Bryan
Journal:  J Org Chem       Date:  1973-05-18       Impact factor: 4.354

6.  Studies with lergotrile mesylate in acromegaly.

Authors:  D L Kleinberg; M Schaaf; A G Frantz
Journal:  Fed Proc       Date:  1978-06

7.  Role of ergot derivatives in the treatment of parkinsonism.

Authors:  D B Calne
Journal:  Fed Proc       Date:  1978-06

8.  The van urk-Salkowski reagent--a sensitive and specific chromogenic reagent for silica gel thin-layer chromatographic detection and identification of indole derivatives.

Authors:  A Ehmann
Journal:  J Chromatogr       Date:  1977-02-11

9.  Galactorrhea: a study of 235 cases, including 48 with pituitary tumors.

Authors:  D L Kleinberg; G L Noel; A G Frantz
Journal:  N Engl J Med       Date:  1977-03-17       Impact factor: 91.245
  9 in total
  2 in total

1.  Biosynthesis of the RNA polymerase inhibitor streptolydigin in Streptomyces lydicus: tailoring modification of 3-methyl-aspartate.

Authors:  Dina H Horna; Cristina Gómez; Carlos Olano; Martina Palomino-Schätzlein; Antonio Pineda-Lucena; Rodrigo J Carbajo; Alfredo F Braña; Carmen Méndez; José A Salas
Journal:  J Bacteriol       Date:  2011-03-11       Impact factor: 3.490

Review 2.  Microbial biotransformation as a tool for drug development based on natural products from mevalonic acid pathway: A review.

Authors:  Mohamed-Elamir F Hegazy; Tarik A Mohamed; Abdelsamed I ElShamy; Abou-El-Hamd H Mohamed; Usama A Mahalel; Eman H Reda; Alaa M Shaheen; Wafaa A Tawfik; Abdelaaty A Shahat; Khalid A Shams; Nahla S Abdel-Azim; Fayza M Hammouda
Journal:  J Adv Res       Date:  2014-11-22       Impact factor: 10.479
  2 in total

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