Literature DB >> 4426703

Soluble antigens of mycelia and spherules in the in vitro detection of immunity to Coccidioides immitis.

S C Deresinski, H B Levine, D A Stevens.   

Abstract

The effect of a Coccidioides immitis spherule-derived antigen (spherulin) upon in vitro thymidine uptake by sensitized and nonsensitized lymphocytes was studied, and optimal conditions for the assay were determined. The mitogenic portion of the antigen was shown to be nondialyzable, as was true for a mycelial-derived antigen (coccidioidin). Concentrations of 20 mug of nondialyzable spherulin solids and 17 mug of nondialyzable coccidioidin solids per ml of culture were shown to be suitable for differentiating skin test-positive from skin test-negative individuals. Comparison with mycelial filtrate suggested spherulin may be a more potent mitogen for sensitized lymphocytes.

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Year:  1974        PMID： 4426703      PMCID： PMC423009          DOI： 10.1128/iai.10.4.700-704.1974

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  16 in total

1.  Variation in lymphocyte reactivity to histoplasmin during the course of chronic pulmonary histoplasmosis.

Authors:  R H Alford; R A Goodwin
Journal:  Am Rev Respir Dis       Date:  1973-07

2.  In vitro and in vivo cellular immunity in anergic miliary tuberculosis.

Authors:  J Waxman; M Lockshin
Journal:  Am Rev Respir Dis       Date:  1973-04

3.  Correlation of lymphocyte transformation with tuberculin skin-test sensitivity.

Authors:  S D Miller; H E Jones
Journal:  Am Rev Respir Dis       Date:  1973-04

4.  Dermal sensitivity to Coccidioides immitis. A comparison of responses elicited in man by spherulin and coccidioidin.

Authors:  H B Levine; A Gonzalez-Ochoa; D R Ten Eyck
Journal:  Am Rev Respir Dis       Date:  1973-03

5.  Serological comparison of the three morphological phases of Coccidioides immitis by the agar gel diffusion method.

Authors:  M E Landay; R W Wheat; N F Conant; E P Lowe
Journal:  J Bacteriol       Date:  1967-01       Impact factor: 3.490

6.  Spherule coccidioidin in delayed dermal sensitivity reactions of experimental animals.

Authors:  H B Levine; J M Cobb; G M Scalarone
Journal:  Sabouraudia       Date:  1969-02

7.  Coccidioidin delayed hypersensitivity: skin test and in vitro lymphocyte reactivities.

Authors:  B Zweiman; D Pappagianis; H Maibach; E A Hildreth
Journal:  J Immunol       Date:  1969-05       Impact factor: 5.422

8.  Correlation of human skin reactivity with lymphocyte transformation induced by mycobacterial antigens and histoplasmin.

Authors:  S D Chaparas; J N Sheagren; A DeMeo; S Hedrick
Journal:  Am Rev Respir Dis       Date:  1970-01

9.  Serological comparison of spherules and arthrospores of Coccidioides immitis.

Authors:  M E Landay; R W Wheat; N F Conant; E P Lowe
Journal:  J Bacteriol       Date:  1967-11       Impact factor: 3.490

10.  Agar-gel precipitin-inhibition test for coccidioidomycosis. II. Serological test antigen studies in agar-gel.

Authors:  J G Ray; J L Converse
Journal:  Appl Microbiol       Date:  1967-09
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  9 in total

Review 1.  Measurement of cellular immunity in human coccidioidomycosis.

Authors:  Neil M Ampel
Journal:  Mycopathologia       Date:  2003       Impact factor: 2.574

2.  In vitro lymphocyte responses of coccidioidin skin test-positive and -negative persons to coccidioidin, spherulin, and a coccidioides cell wall antigen.

Authors:  R A Cox; E Brummer; G Lecara
Journal:  Infect Immun       Date:  1977-03       Impact factor: 3.441

3.  The prevalence of cellular immunity to coccidioidomycosis in a highly endemic area.

Authors:  M J Hicks; R M Hagaman; R A Barbee
Journal:  West J Med       Date:  1986-04

4.  Chemotaxigenic activity of extracts from the mycelial and spherule phases of Coccidioides immitis for human polymorphonuclear leukocytes.

Authors:  J N Galgiani; R A Isenberg; D A Stevens
Journal:  Infect Immun       Date:  1978-09       Impact factor: 3.441

5.  Cell-mediated immune responses in patients with paracoccidioidomycosis.

Authors:  P W Mok; D L Greer
Journal:  Clin Exp Immunol       Date:  1977-04       Impact factor: 4.330

6.  Complement activation by Coccidioides immitis: in vitro and clinical studies.

Authors:  J N Galgiani; P Yam; L D Petz; P L Williams; D A Stevens
Journal:  Infect Immun       Date:  1980-06       Impact factor: 3.441

Review 7.  Coccidioidomycosis.

Authors:  J N Galgiani
Journal:  West J Med       Date:  1993-08

8.  Stimulation and suppression of cell-mediated immunity by endosporulation antigens of Coccidioides immitis.

Authors:  C Brass; H B Levine; D A Stevens
Journal:  Infect Immun       Date:  1982-02       Impact factor: 3.441

Review 9.  Coccidioides Species: A Review of Basic Research: 2022.

Authors:  Theo N Kirkland; David A Stevens; Chiung-Yu Hung; Sinem Beyhan; John W Taylor; Lisa F Shubitz; Sascha H Duttke; Arash Heidari; Royce H Johnson; Stanley C Deresinski; Antje Lauer; Joshua Fierer
Journal:  J Fungi (Basel)       Date:  2022-08-16
  9 in total

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